An efficient, asymmetric organocatalyst-mediated conjugate addition of nitroalkanes to unsaturated cyclic and acyclic ketones

Claire E.T. Mitchell, Stacey E. Brenner, Jorge García-Fortanet, Steven V. Ley

Research output: Contribution to journalArticlepeer-review

90 Scopus citations

Abstract

5-Pyrrolidin-2-yltetrazole is a versatile organocatalyst for the asymmetric conjugate addition of nitroalkanes to enones. Using this catalyst, this transformation requires short reaction times, tolerates a broad substrate scope, and possibly proceeds via generation of an iminium species.

Original languageEnglish (US)
Pages (from-to)2039-2049
Number of pages11
JournalOrganic and Biomolecular Chemistry
Volume4
Issue number10
DOIs
StatePublished - 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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