An efficient, asymmetric organocatalyst-mediated conjugate addition of nitroalkanes to unsaturated cyclic and acyclic ketones

Claire E.T. Mitchell; Stacey E. Brenner; Jorge García-Fortanet; Steven V. Ley

doi:10.1039/b601877g

An efficient, asymmetric organocatalyst-mediated conjugate addition of nitroalkanes to unsaturated cyclic and acyclic ketones

Claire E.T. Mitchell, Stacey E. Brenner, Jorge García-Fortanet, Steven V. Ley

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

5-Pyrrolidin-2-yltetrazole is a versatile organocatalyst for the asymmetric conjugate addition of nitroalkanes to enones. Using this catalyst, this transformation requires short reaction times, tolerates a broad substrate scope, and possibly proceeds via generation of an iminium species.

Original language	English (US)
Pages (from-to)	2039-2049
Number of pages	11
Journal	Organic and Biomolecular Chemistry
Volume	4
Issue number	10
DOIs	https://doi.org/10.1039/b601877g
State	Published - 2006
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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abstract = "5-Pyrrolidin-2-yltetrazole is a versatile organocatalyst for the asymmetric conjugate addition of nitroalkanes to enones. Using this catalyst, this transformation requires short reaction times, tolerates a broad substrate scope, and possibly proceeds via generation of an iminium species.",

author = "Mitchell, {Claire E.T.} and Brenner, {Stacey E.} and Jorge Garc{\'i}a-Fortanet and Ley, {Steven V.}",

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AU - García-Fortanet, Jorge

AU - Ley, Steven V.

PY - 2006

Y1 - 2006

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AB - 5-Pyrrolidin-2-yltetrazole is a versatile organocatalyst for the asymmetric conjugate addition of nitroalkanes to enones. Using this catalyst, this transformation requires short reaction times, tolerates a broad substrate scope, and possibly proceeds via generation of an iminium species.

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An efficient, asymmetric organocatalyst-mediated conjugate addition of nitroalkanes to unsaturated cyclic and acyclic ketones

Abstract

All Science Journal Classification (ASJC) codes

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