An endogenous Su(Hw) insulator separates the yellow gene from the Achaete-scute gene complex in Drosophila

Anton Golovnin, Inna Birukova, Olga Romanova, Margarita Silicheva, Akeksander Parshikov, Ekaterina Savitskaya, Vincenzo Pirrotta, Pavel Georgiev

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

The best characterized chromatin insulator in Drosophila is the Suppressor of Hairy wing binding region contained within the gypsy retrotransposon. Although cellular functions have been suggested, no role has been found yet for the multitude of endogenous Suppressor of Hairy wing binding sites. Here we show that two Suppressor of Hairy wing binding sites in the intergenic region between the yellow gene and the Achaete-scute gene complex form a functional insulator. Genetic analysis shows that at least two proteins, Suppressor of Hairy wing and Modifier of MDG4, required for the activity of this insulator, are involved in the transcriptional regulation of Achaete-scute.

Original languageEnglish (US)
Pages (from-to)3249-3258
Number of pages10
JournalDevelopment
Volume130
Issue number14
DOIs
StatePublished - Jul 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology

Keywords

  • Achaete-scute complex
  • Drosophila melanogaste
  • Enhancer blocking
  • Insulator
  • Mod(mdg4)
  • Su(Hw)

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