An essential role for T H 2-type responses in limiting acute tissue damage during experimental helminth infection

Fei Chen, Zhugong Liu, Wenhui Wu, Cristina Rozo, Scott Bowdridge, Ariel Millman, Nico Van Rooijen, Joseph F. Urban, Thomas A. Wynn, William C. Gause

Research output: Contribution to journalArticlepeer-review

276 Scopus citations


Helminths induce potent T helper 2 (T H 2)-type immune responses that can mediate worm expulsion, but the role of this response in controlling the acute tissue damage caused by migrating multicellular parasites through vital tissues remains uncertain. We used a helminth infection model in which parasitic nematode larvae migrate transiently through the lung, resulting in hemorrhage and inflammation. We found that IL-17 initially contributed to inflammation and lung damage, whereas subsequent IL-4 receptor (IL-4R) signaling reduced elevations in IL-17 mRNA levels, enhanced the expression of insulin-like growth factor 1 (IGF-1) and IL-10 and stimulated the development of M2 macrophages, all of which contributed to the rapid resolution of tissue damage. These studies indicate an essential role for T H 2-type immune responses in mediating acute wound healing during helminth infection.

Original languageEnglish (US)
Pages (from-to)260-266
Number of pages7
JournalNature medicine
Issue number2
StatePublished - Feb 2012

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)


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