An essential role for T H 2-type responses in limiting acute tissue damage during experimental helminth infection

Fei Chen, Zhugong Liu, Wenhui Wu, Cristina Rozo, Scott Bowdridge, Ariel Millman, Nico Van Rooijen, Joseph F. Urban, Thomas A. Wynn, William Gause

Research output: Contribution to journalArticle

226 Citations (Scopus)

Abstract

Helminths induce potent T helper 2 (T H 2)-type immune responses that can mediate worm expulsion, but the role of this response in controlling the acute tissue damage caused by migrating multicellular parasites through vital tissues remains uncertain. We used a helminth infection model in which parasitic nematode larvae migrate transiently through the lung, resulting in hemorrhage and inflammation. We found that IL-17 initially contributed to inflammation and lung damage, whereas subsequent IL-4 receptor (IL-4R) signaling reduced elevations in IL-17 mRNA levels, enhanced the expression of insulin-like growth factor 1 (IGF-1) and IL-10 and stimulated the development of M2 macrophages, all of which contributed to the rapid resolution of tissue damage. These studies indicate an essential role for T H 2-type immune responses in mediating acute wound healing during helminth infection.

Original languageEnglish (US)
Pages (from-to)260-266
Number of pages7
JournalNature medicine
Volume18
Issue number2
DOIs
StatePublished - Feb 1 2012

Fingerprint

Helminths
Interleukin-17
Tissue
Infection
Interleukin-4 Receptors
Macrophages
Somatomedins
Interleukin-10
Wound Healing
Larva
Pneumonia
Parasites
Hemorrhage
Inflammation
Lung
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Chen, Fei ; Liu, Zhugong ; Wu, Wenhui ; Rozo, Cristina ; Bowdridge, Scott ; Millman, Ariel ; Van Rooijen, Nico ; Urban, Joseph F. ; Wynn, Thomas A. ; Gause, William. / An essential role for T H 2-type responses in limiting acute tissue damage during experimental helminth infection. In: Nature medicine. 2012 ; Vol. 18, No. 2. pp. 260-266.
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Chen, F, Liu, Z, Wu, W, Rozo, C, Bowdridge, S, Millman, A, Van Rooijen, N, Urban, JF, Wynn, TA & Gause, W 2012, 'An essential role for T H 2-type responses in limiting acute tissue damage during experimental helminth infection', Nature medicine, vol. 18, no. 2, pp. 260-266. https://doi.org/10.1038/nm.2628

An essential role for T H 2-type responses in limiting acute tissue damage during experimental helminth infection. / Chen, Fei; Liu, Zhugong; Wu, Wenhui; Rozo, Cristina; Bowdridge, Scott; Millman, Ariel; Van Rooijen, Nico; Urban, Joseph F.; Wynn, Thomas A.; Gause, William.

In: Nature medicine, Vol. 18, No. 2, 01.02.2012, p. 260-266.

Research output: Contribution to journalArticle

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