An evolutionarily conserved family of accessory subunits of K+ channels

Shi Qing Cai, Ki Ho Park, Federico Sesti

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Accessory subunits are an essential feature of voltage-gated potassium (Kv) channels. They determine traf- ficking to the plasma membrane, surface expression, gating, permeation, and pharmacology. At least three distinct classes of accessory subunits including the KCNE family can regulate Kv channel function. KCNE genes encode integral membrane proteins with a single transmembrane domain. KCNE genes span the eukaryotic kingdom and, in mutated form, can cause acquired and congenital disease. Here we review genetic, physiological, and biophysical aspects of KCNE proteins with particular emphasis on the Caenorhabditis elegans subfamily.

Original languageEnglish (US)
Pages (from-to)91-99
Number of pages9
JournalCell biochemistry and biophysics
Volume46
Issue number1
DOIs
StatePublished - Aug 1 2006

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Cell Biology

Keywords

  • C. elegans
  • Chemotaxis
  • KCNE
  • Kinase

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