An immunocompromised child with bloodstream infection caused by two Escherichia coli strains, one harboring NDM-5 and the other harboring OXA-48-like carbapenemase

M. Earth Hasassri; Thomas G. Boyce; Andrew Norgan; Scott A. Cunningham; Patricio R. Jeraldo; Scott Weissman; Robin Patel; Ritu Banerjee; Jason M. Pogue; Keith S. Kaye

doi:10.1128/AAC.03118-15

An immunocompromised child with bloodstream infection caused by two Escherichia coli strains, one harboring NDM-5 and the other harboring OXA-48-like carbapenemase

M. Earth Hasassri, Thomas G. Boyce, Andrew Norgan, Scott A. Cunningham, Patricio R. Jeraldo, Scott Weissman, Robin Patel, Ritu Banerjee, Jason M. Pogue, Keith S. Kaye

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We describe a 16-year-old neutropenic patient from the Middle East with bloodstream infection caused by two carbapenemase-producing Escherichia coli isolates that we characterized by whole-genome sequencing. While one displayed meropenem resistance and was bla_NDM positive, the other demonstrated meropenem susceptibility yet harbored bla_OXA181 (which encodes a bla_OXA48-like enzyme). This report highlights the challenge of laboratory detection of bla_OXA48-like enzymes and the clinical implications of genotypic resistance detection in carbapenemase-producing Enterobacteriaceae.

Original language	English (US)
Pages (from-to)	3270-3275
Number of pages	6
Journal	Antimicrobial agents and chemotherapy
Volume	60
Issue number	6
DOIs	https://doi.org/10.1128/AAC.03118-15
State	Published - Jun 2016
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Hasassri, M. E., Boyce, T. G., Norgan, A., Cunningham, S. A., Jeraldo, P. R., Weissman, S., Patel, R., Banerjee, R., Pogue, J. M., & Kaye, K. S. (2016). An immunocompromised child with bloodstream infection caused by two Escherichia coli strains, one harboring NDM-5 and the other harboring OXA-48-like carbapenemase. Antimicrobial agents and chemotherapy, 60(6), 3270-3275. https://doi.org/10.1128/AAC.03118-15

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title = "An immunocompromised child with bloodstream infection caused by two Escherichia coli strains, one harboring NDM-5 and the other harboring OXA-48-like carbapenemase",

abstract = "We describe a 16-year-old neutropenic patient from the Middle East with bloodstream infection caused by two carbapenemase-producing Escherichia coli isolates that we characterized by whole-genome sequencing. While one displayed meropenem resistance and was blaNDM positive, the other demonstrated meropenem susceptibility yet harbored blaOXA181 (which encodes a blaOXA48-like enzyme). This report highlights the challenge of laboratory detection of blaOXA48-like enzymes and the clinical implications of genotypic resistance detection in carbapenemase-producing Enterobacteriaceae.",

author = "Hasassri, {M. Earth} and Boyce, {Thomas G.} and Andrew Norgan and Cunningham, {Scott A.} and Jeraldo, {Patricio R.} and Scott Weissman and Robin Patel and Ritu Banerjee and Pogue, {Jason M.} and Kaye, {Keith S.}",

year = "2016",

month = jun,

doi = "10.1128/AAC.03118-15",

language = "English (US)",

volume = "60",

pages = "3270--3275",

journal = "Antimicrobial agents and chemotherapy",

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Hasassri, ME, Boyce, TG, Norgan, A, Cunningham, SA, Jeraldo, PR, Weissman, S, Patel, R, Banerjee, R, Pogue, JM & Kaye, KS 2016, 'An immunocompromised child with bloodstream infection caused by two Escherichia coli strains, one harboring NDM-5 and the other harboring OXA-48-like carbapenemase', Antimicrobial agents and chemotherapy, vol. 60, no. 6, pp. 3270-3275. https://doi.org/10.1128/AAC.03118-15

An immunocompromised child with bloodstream infection caused by two Escherichia coli strains, one harboring NDM-5 and the other harboring OXA-48-like carbapenemase. / Hasassri, M. Earth; Boyce, Thomas G.; Norgan, Andrew et al.
In: Antimicrobial agents and chemotherapy, Vol. 60, No. 6, 06.2016, p. 3270-3275.

Research output: Contribution to journal › Article › peer-review

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AU - Hasassri, M. Earth

AU - Boyce, Thomas G.

AU - Norgan, Andrew

AU - Cunningham, Scott A.

AU - Jeraldo, Patricio R.

AU - Weissman, Scott

AU - Patel, Robin

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AU - Kaye, Keith S.

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AB - We describe a 16-year-old neutropenic patient from the Middle East with bloodstream infection caused by two carbapenemase-producing Escherichia coli isolates that we characterized by whole-genome sequencing. While one displayed meropenem resistance and was blaNDM positive, the other demonstrated meropenem susceptibility yet harbored blaOXA181 (which encodes a blaOXA48-like enzyme). This report highlights the challenge of laboratory detection of blaOXA48-like enzymes and the clinical implications of genotypic resistance detection in carbapenemase-producing Enterobacteriaceae.

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An immunocompromised child with bloodstream infection caused by two Escherichia coli strains, one harboring NDM-5 and the other harboring OXA-48-like carbapenemase

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