An international multicenter study of antimicrobial consumption and resistance in Staphylococcus aureus isolates from 15 hospitals in 14 countries

Henrik Westh, Christina Scheel Zinn, Vibeke Thamdrup Rosdahl, E. Couto, M. Struelens, A. MacGowan, O. Meurman, J. Etienne, D. Milatovic, C. Wallrauch, O. Paniara, E. E. Udo, J. Miciulleviciené, R. Yasin, N. Cowley, S. Lang, T. Hofstad, A. Digranes, G. Mlynarczyk, A. G. DuseF. Marco, T. Trilla, M. Walder, H. Laurell, D. A. Bruckner, M. L. Wilson, Melvin Weinstein, J. W. Pearman, G. Coombs

Research output: Contribution to journalArticle

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Abstract

Antibiotic consumption during 1996 was measured in 15 large hospitals from 14 countries and 3000 consecutive Staphylococcus aureus samples were collected, allowing calculation of local resistance rates and typing of isolates. Antibiotic consumption data were converted to defined daily doses (DDD), and similar antibiotics were grouped if they belonged to the same therapeutic subgroup. Variations in hospital size were corrected by using DDD per 1000 bed-days. The total antibiotic consumption in the 15 hospitals varied between 296 DDD/1000 bed-days and 1108 DDD/1000 bed-days. Differences in the usage of therapeutical subgroups of antimicrobials varied significantly between hospitals. A positive correlation was found between S. aureus resistance to methicillin (MRSA) and consumption of β-lactam combinations, between resistance to quinolones and consumption of β-lactam combinations and carbapenems and resistance to aminoglycosides and consumption of β-lactam combinations. The consumption of β-lactamase-sensitive antibiotics was negatively correlated to resistance to methicillin, quinolones, and aminoglycosides. Usage of the different antimicrobial therapeutical subgroups was also correlated. Consumption of β-lactamase-sensitive antibiotics (penicillin) was positively correlated to consumption of β-lactamase- resistant penicillins and negatively correlated to consumption of carbapenems, quinolones, and glycopeptides, whereas consumption of cephalosporins was positively correlated to consumption of aminoglycosides, quinolones, and glycopeptides. In this study of hospitals with MRSA prevalence of between 0% and 63%, significant correlations were found between resistance and consumption of antimicrobials. These findings support the importance of antimicrobial consumption on resistance. An accompanying paper addresses the issue of antibiotic resistance and clonality of isolates.

Original languageEnglish (US)
Pages (from-to)169-176
Number of pages8
JournalMicrobial Drug Resistance
Volume10
Issue number2
DOIs
StatePublished - Jun 1 2004

Fingerprint

Multicenter Studies
Quinolones
Staphylococcus aureus
Lactams
Anti-Bacterial Agents
Aminoglycosides
Methicillin Resistance
Carbapenems
Glycopeptides
Methicillin-Resistant Staphylococcus aureus
Penicillins
Health Facility Size
Cephalosporins
Microbial Drug Resistance
Therapeutics

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Pharmacology
  • Microbiology (medical)

Cite this

Westh, Henrik ; Zinn, Christina Scheel ; Rosdahl, Vibeke Thamdrup ; Couto, E. ; Struelens, M. ; MacGowan, A. ; Meurman, O. ; Etienne, J. ; Milatovic, D. ; Wallrauch, C. ; Paniara, O. ; Udo, E. E. ; Miciulleviciené, J. ; Yasin, R. ; Cowley, N. ; Lang, S. ; Hofstad, T. ; Digranes, A. ; Mlynarczyk, G. ; Duse, A. G. ; Marco, F. ; Trilla, T. ; Walder, M. ; Laurell, H. ; Bruckner, D. A. ; Wilson, M. L. ; Weinstein, Melvin ; Pearman, J. W. ; Coombs, G. / An international multicenter study of antimicrobial consumption and resistance in Staphylococcus aureus isolates from 15 hospitals in 14 countries. In: Microbial Drug Resistance. 2004 ; Vol. 10, No. 2. pp. 169-176.
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abstract = "Antibiotic consumption during 1996 was measured in 15 large hospitals from 14 countries and 3000 consecutive Staphylococcus aureus samples were collected, allowing calculation of local resistance rates and typing of isolates. Antibiotic consumption data were converted to defined daily doses (DDD), and similar antibiotics were grouped if they belonged to the same therapeutic subgroup. Variations in hospital size were corrected by using DDD per 1000 bed-days. The total antibiotic consumption in the 15 hospitals varied between 296 DDD/1000 bed-days and 1108 DDD/1000 bed-days. Differences in the usage of therapeutical subgroups of antimicrobials varied significantly between hospitals. A positive correlation was found between S. aureus resistance to methicillin (MRSA) and consumption of β-lactam combinations, between resistance to quinolones and consumption of β-lactam combinations and carbapenems and resistance to aminoglycosides and consumption of β-lactam combinations. The consumption of β-lactamase-sensitive antibiotics was negatively correlated to resistance to methicillin, quinolones, and aminoglycosides. Usage of the different antimicrobial therapeutical subgroups was also correlated. Consumption of β-lactamase-sensitive antibiotics (penicillin) was positively correlated to consumption of β-lactamase- resistant penicillins and negatively correlated to consumption of carbapenems, quinolones, and glycopeptides, whereas consumption of cephalosporins was positively correlated to consumption of aminoglycosides, quinolones, and glycopeptides. In this study of hospitals with MRSA prevalence of between 0{\%} and 63{\%}, significant correlations were found between resistance and consumption of antimicrobials. These findings support the importance of antimicrobial consumption on resistance. An accompanying paper addresses the issue of antibiotic resistance and clonality of isolates.",
author = "Henrik Westh and Zinn, {Christina Scheel} and Rosdahl, {Vibeke Thamdrup} and E. Couto and M. Struelens and A. MacGowan and O. Meurman and J. Etienne and D. Milatovic and C. Wallrauch and O. Paniara and Udo, {E. E.} and J. Miciullevicien{\'e} and R. Yasin and N. Cowley and S. Lang and T. Hofstad and A. Digranes and G. Mlynarczyk and Duse, {A. G.} and F. Marco and T. Trilla and M. Walder and H. Laurell and Bruckner, {D. A.} and Wilson, {M. L.} and Melvin Weinstein and Pearman, {J. W.} and G. Coombs",
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Westh, H, Zinn, CS, Rosdahl, VT, Couto, E, Struelens, M, MacGowan, A, Meurman, O, Etienne, J, Milatovic, D, Wallrauch, C, Paniara, O, Udo, EE, Miciulleviciené, J, Yasin, R, Cowley, N, Lang, S, Hofstad, T, Digranes, A, Mlynarczyk, G, Duse, AG, Marco, F, Trilla, T, Walder, M, Laurell, H, Bruckner, DA, Wilson, ML, Weinstein, M, Pearman, JW & Coombs, G 2004, 'An international multicenter study of antimicrobial consumption and resistance in Staphylococcus aureus isolates from 15 hospitals in 14 countries', Microbial Drug Resistance, vol. 10, no. 2, pp. 169-176. https://doi.org/10.1089/1076629041310019

An international multicenter study of antimicrobial consumption and resistance in Staphylococcus aureus isolates from 15 hospitals in 14 countries. / Westh, Henrik; Zinn, Christina Scheel; Rosdahl, Vibeke Thamdrup; Couto, E.; Struelens, M.; MacGowan, A.; Meurman, O.; Etienne, J.; Milatovic, D.; Wallrauch, C.; Paniara, O.; Udo, E. E.; Miciulleviciené, J.; Yasin, R.; Cowley, N.; Lang, S.; Hofstad, T.; Digranes, A.; Mlynarczyk, G.; Duse, A. G.; Marco, F.; Trilla, T.; Walder, M.; Laurell, H.; Bruckner, D. A.; Wilson, M. L.; Weinstein, Melvin; Pearman, J. W.; Coombs, G.

In: Microbial Drug Resistance, Vol. 10, No. 2, 01.06.2004, p. 169-176.

Research output: Contribution to journalArticle

TY - JOUR

T1 - An international multicenter study of antimicrobial consumption and resistance in Staphylococcus aureus isolates from 15 hospitals in 14 countries

AU - Westh, Henrik

AU - Zinn, Christina Scheel

AU - Rosdahl, Vibeke Thamdrup

AU - Couto, E.

AU - Struelens, M.

AU - MacGowan, A.

AU - Meurman, O.

AU - Etienne, J.

AU - Milatovic, D.

AU - Wallrauch, C.

AU - Paniara, O.

AU - Udo, E. E.

AU - Miciulleviciené, J.

AU - Yasin, R.

AU - Cowley, N.

AU - Lang, S.

AU - Hofstad, T.

AU - Digranes, A.

AU - Mlynarczyk, G.

AU - Duse, A. G.

AU - Marco, F.

AU - Trilla, T.

AU - Walder, M.

AU - Laurell, H.

AU - Bruckner, D. A.

AU - Wilson, M. L.

AU - Weinstein, Melvin

AU - Pearman, J. W.

AU - Coombs, G.

PY - 2004/6/1

Y1 - 2004/6/1

N2 - Antibiotic consumption during 1996 was measured in 15 large hospitals from 14 countries and 3000 consecutive Staphylococcus aureus samples were collected, allowing calculation of local resistance rates and typing of isolates. Antibiotic consumption data were converted to defined daily doses (DDD), and similar antibiotics were grouped if they belonged to the same therapeutic subgroup. Variations in hospital size were corrected by using DDD per 1000 bed-days. The total antibiotic consumption in the 15 hospitals varied between 296 DDD/1000 bed-days and 1108 DDD/1000 bed-days. Differences in the usage of therapeutical subgroups of antimicrobials varied significantly between hospitals. A positive correlation was found between S. aureus resistance to methicillin (MRSA) and consumption of β-lactam combinations, between resistance to quinolones and consumption of β-lactam combinations and carbapenems and resistance to aminoglycosides and consumption of β-lactam combinations. The consumption of β-lactamase-sensitive antibiotics was negatively correlated to resistance to methicillin, quinolones, and aminoglycosides. Usage of the different antimicrobial therapeutical subgroups was also correlated. Consumption of β-lactamase-sensitive antibiotics (penicillin) was positively correlated to consumption of β-lactamase- resistant penicillins and negatively correlated to consumption of carbapenems, quinolones, and glycopeptides, whereas consumption of cephalosporins was positively correlated to consumption of aminoglycosides, quinolones, and glycopeptides. In this study of hospitals with MRSA prevalence of between 0% and 63%, significant correlations were found between resistance and consumption of antimicrobials. These findings support the importance of antimicrobial consumption on resistance. An accompanying paper addresses the issue of antibiotic resistance and clonality of isolates.

AB - Antibiotic consumption during 1996 was measured in 15 large hospitals from 14 countries and 3000 consecutive Staphylococcus aureus samples were collected, allowing calculation of local resistance rates and typing of isolates. Antibiotic consumption data were converted to defined daily doses (DDD), and similar antibiotics were grouped if they belonged to the same therapeutic subgroup. Variations in hospital size were corrected by using DDD per 1000 bed-days. The total antibiotic consumption in the 15 hospitals varied between 296 DDD/1000 bed-days and 1108 DDD/1000 bed-days. Differences in the usage of therapeutical subgroups of antimicrobials varied significantly between hospitals. A positive correlation was found between S. aureus resistance to methicillin (MRSA) and consumption of β-lactam combinations, between resistance to quinolones and consumption of β-lactam combinations and carbapenems and resistance to aminoglycosides and consumption of β-lactam combinations. The consumption of β-lactamase-sensitive antibiotics was negatively correlated to resistance to methicillin, quinolones, and aminoglycosides. Usage of the different antimicrobial therapeutical subgroups was also correlated. Consumption of β-lactamase-sensitive antibiotics (penicillin) was positively correlated to consumption of β-lactamase- resistant penicillins and negatively correlated to consumption of carbapenems, quinolones, and glycopeptides, whereas consumption of cephalosporins was positively correlated to consumption of aminoglycosides, quinolones, and glycopeptides. In this study of hospitals with MRSA prevalence of between 0% and 63%, significant correlations were found between resistance and consumption of antimicrobials. These findings support the importance of antimicrobial consumption on resistance. An accompanying paper addresses the issue of antibiotic resistance and clonality of isolates.

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