Abstract
We have developed recombinant vesicular stomatitis virus (VSV) vectors expressing the Yersinia pestis lcrV gene. These vectors, given intranasally to mice, induced high antibody titers to the LcrV protein and protected against intranasal (pulmonary) challenge with Y. pestis. High-level protection was dependent on using an optimized VSV vector that expressed high levels of the LcrV protein from an lcrV gene placed in the first position in the VSV genome, followed by a single boost. This VSV-based vaccine vector system has potential as a plague vaccine protecting against virulent strains lacking the F1 protein.
Original language | English (US) |
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Pages (from-to) | 741-750 |
Number of pages | 10 |
Journal | Vaccine |
Volume | 25 |
Issue number | 4 |
DOIs | |
State | Published - Jan 8 2007 |
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- General Immunology and Microbiology
- General Veterinary
- Public Health, Environmental and Occupational Health
- Infectious Diseases
Keywords
- Plague vaccine
- Vesicular stomatitis virus
- Yersinia pestis