An overview of recent patents on musculoskeletal interface tissue engineering

Rohit T. Rao, Daniel P. Browe, Christopher J. Lowe, Joseph W. Freeman

Research output: Contribution to journalReview article

5 Scopus citations


Interface tissue engineering involves the development of engineered grafts that promote integration between multiple tissue types. Musculoskeletal tissue interfaces are critical to the safe and efficient transmission of mechanical forces between multiple musculoskeletal tissues, e.g., between ligament and bone tissue. However, these interfaces often do not physiologically regenerate upon injury, resulting in impaired tissue function. Therefore, interface tissue engineering approaches are considered to be particularly relevant for the structural restoration of musculoskeletal tissues interfaces. In this article, we provide an overview of the various strategies used for engineering musculoskeletal tissue interfaces with a specific focus on the recent important patents that have been issued for inventions that were specifically designed for engineering musculoskeletal interfaces as well as those that show promise to be adapted for this purpose.

Original languageEnglish (US)
Pages (from-to)53-67
Number of pages15
JournalConnective Tissue Research
Issue number1
StatePublished - Jan 2 2016

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Biochemistry
  • Orthopedics and Sports Medicine
  • Molecular Biology
  • Cell Biology


  • Gradient scaffolds
  • interface tissue engineering
  • multiphase scaffolds
  • musculoskeletal tissue interfaces
  • scaffoldless tissue engineering

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