An overview of the structures of protein-DNA complexes

Nicholas M. Luscombe, Susan E. Austin, Helen M. Berman, Janet M. Thornton

Research output: Contribution to journalArticlepeer-review

102 Scopus citations


On the basis of a structural analysis of 240 protein-DNA complexes contained in the Protein Data Bank (PDB), we have classified the DNA-binding proteins involved into eight different structural/functional groups, which are further classified into 54 structural families. Here we present this classification and review the functions, structures and binding interactions of these protein-DNA complexes.

Original languageEnglish (US)
Pages (from-to)XIII-XIV
JournalGenome biology
Issue number1
StatePublished - 2000

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Cell Biology


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