An overview of the structures of protein-DNA complexes

Nicholas M. Luscombe, Susan E. Austin, Helen Berman, Janet M. Thornton

Research output: Contribution to journalArticle

86 Scopus citations


On the basis of a structural analysis of 240 protein-DNA complexes contained in the Protein Data Bank (PDB), we have classified the DNA-binding proteins involved into eight different structural/functional groups, which are further classified into 54 structural families. Here we present this classification and review the functions, structures and binding interactions of these protein-DNA complexes.

Original languageEnglish (US)
JournalGenome biology
Issue number1
StatePublished - Dec 1 2000

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Cell Biology

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    Luscombe, N. M., Austin, S. E., Berman, H., & Thornton, J. M. (2000). An overview of the structures of protein-DNA complexes. Genome biology, 1(1).