Abstract
Afferent activity from the reproductive tract activates intrinsic pain attenuating processes. For example, analgesia results from vaginocervical mechano-stimulation in nonpregnant rats and occurs during pregnancy and parturition. In the present study, the effect of uterocervical mechanostimulation on pain thresholds was investigated in order to determine whether direct stimulation of the uterine cervix could play a role in the analgesia of pregnancy. Uterocervical mechanostimulation was applied to nonpregnant rats via a silastic disc implanted in the uterus. The disc abutted against the cervix and was attached to a thread externalized through the vaginal orifice. Application of a force of 150 g, but not 100 g, produced a significant increase in tail flick latency (110.4 ± 40.6%, P < 0.03). This effect was abolished by pelvic neurectomy, but was not altered by hypogastric neurectomy. Stimulation of the uterine cervix in combined pelvic and hypogastric neurectomy rats produced a decrease in tail flick latency. These results indicate that the analgesia that occurs during pregnancy and/or parturition may result, at least in part, from the uterocervical mechanostimulation that occurs during this condition.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 299-302 |
| Number of pages | 4 |
| Journal | Brain research |
| Volume | 566 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Dec 6 1991 |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology
Keywords
- Analgesia
- Hypogastric nerve
- Pelvic nerve
- Tail flick
- Uterus
Cite this
}
Analgesia is produced by uterocervical mechanostimulation in rats : roles of afferent nerves and implications for analgesia of pregnancy and parturition. / R. Gintzler, Alan; Komisaruk, Barry R.
In: Brain research, Vol. 566, No. 1-2, 06.12.1991, p. 299-302.Research output: Contribution to journal › Article
TY - JOUR
T1 - Analgesia is produced by uterocervical mechanostimulation in rats
T2 - roles of afferent nerves and implications for analgesia of pregnancy and parturition
AU - R. Gintzler, Alan
AU - Komisaruk, Barry R.
PY - 1991/12/6
Y1 - 1991/12/6
N2 - Afferent activity from the reproductive tract activates intrinsic pain attenuating processes. For example, analgesia results from vaginocervical mechano-stimulation in nonpregnant rats and occurs during pregnancy and parturition. In the present study, the effect of uterocervical mechanostimulation on pain thresholds was investigated in order to determine whether direct stimulation of the uterine cervix could play a role in the analgesia of pregnancy. Uterocervical mechanostimulation was applied to nonpregnant rats via a silastic disc implanted in the uterus. The disc abutted against the cervix and was attached to a thread externalized through the vaginal orifice. Application of a force of 150 g, but not 100 g, produced a significant increase in tail flick latency (110.4 ± 40.6%, P < 0.03). This effect was abolished by pelvic neurectomy, but was not altered by hypogastric neurectomy. Stimulation of the uterine cervix in combined pelvic and hypogastric neurectomy rats produced a decrease in tail flick latency. These results indicate that the analgesia that occurs during pregnancy and/or parturition may result, at least in part, from the uterocervical mechanostimulation that occurs during this condition.
AB - Afferent activity from the reproductive tract activates intrinsic pain attenuating processes. For example, analgesia results from vaginocervical mechano-stimulation in nonpregnant rats and occurs during pregnancy and parturition. In the present study, the effect of uterocervical mechanostimulation on pain thresholds was investigated in order to determine whether direct stimulation of the uterine cervix could play a role in the analgesia of pregnancy. Uterocervical mechanostimulation was applied to nonpregnant rats via a silastic disc implanted in the uterus. The disc abutted against the cervix and was attached to a thread externalized through the vaginal orifice. Application of a force of 150 g, but not 100 g, produced a significant increase in tail flick latency (110.4 ± 40.6%, P < 0.03). This effect was abolished by pelvic neurectomy, but was not altered by hypogastric neurectomy. Stimulation of the uterine cervix in combined pelvic and hypogastric neurectomy rats produced a decrease in tail flick latency. These results indicate that the analgesia that occurs during pregnancy and/or parturition may result, at least in part, from the uterocervical mechanostimulation that occurs during this condition.
KW - Analgesia
KW - Hypogastric nerve
KW - Pelvic nerve
KW - Tail flick
KW - Uterus
UR - http://www.scopus.com/inward/record.url?scp=0025999350&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025999350&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(91)91713-B
DO - 10.1016/0006-8993(91)91713-B
M3 - Article
C2 - 1814546
AN - SCOPUS:0025999350
VL - 566
SP - 299
EP - 302
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1-2
ER -