Analysis of blood lead levels of young children in Flint, Michigan before and during the 18-month switch to Flint River water

Hernán F. Gómez, Dominic A. Borgialli, Mahesh Sharman, Keneil K. Shah, Anthony J. Scolpino, James M. Oleske, John D. Bogden

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background: The toxicity of lead, like any xenobiotic, is directly linked to the duration of exposure and toxin concentration in the body. The elevation in blood lead levels (BLLs) in young Flint, Michigan children noted in time-periods before, and during the 18-month exposure to Flint River water (FRW) from 25 April 2014 to 15 October 2015 is well-known internationally. The length of time BLLs were elevated is unknown, yet key in understanding the potential health impact of the event. The objective of this study was to evaluate whether BLLs in Flint children were increased during the entire 18-month FRW exposure compared to similar earlier time periods. Methods: We conducted a retrospective study analyzing BLLs from Flint children aged 5 years and under. The geometric mean (GM) BLLs and percentages of BLLs ≥5.0 μg/dL in Period I: 25 April 2006 to 15 October 2007 (earliest timeframe available for study) and Period II: 25 April 2012 to 15 October 2013 (timeframe immediately before the water switch), were compared to Period III, 25 April 2014 to 15 October 2015 (FRW exposure). Results: There were 5663 BLLs available for study. GM ± SE BLLs decreased from 2.19 ± 0.03 μg/dL in Period I to 1.47 ± 0.02 μg/dL in Period II [95% CI, 0.64, 0.79]; p<.001 and decreased further to 1.32 ± 0.02 µg/dL during the FRW Period III [95% CI, 0.79, 0.95]; p<.001. The percentage of BLLs ≥5.0 μg/dL decreased from Period I (10.6%) to Period II (3.3%) [95% CI, 5.7, 8.8]; p<.001 and from Period I to Period III (3.9%) [95% CI, 5.0, 8.2]; p=.002. The 0.6% increase from Period II to Period III was not statistically significant [95% CI, −1.9, 0.57]; p=.30. Conclusion: Analyses of GM and percentages ≥5.0 μg/dL of BLLs do not support the occurrence of a global increase in BLLs in young children of Flint during the entire 18-month period of FRW exposure.

Original languageEnglish (US)
Pages (from-to)790-797
Number of pages8
JournalClinical Toxicology
Volume57
Issue number9
DOIs
StatePublished - Sep 2 2019

All Science Journal Classification (ASJC) codes

  • Toxicology

Keywords

  • Centers for Disease Control and Prevention
  • Flint
  • Flint water crisis
  • Michigan
  • blood lead levels
  • children
  • geocoding

Fingerprint

Dive into the research topics of 'Analysis of blood lead levels of young children in Flint, Michigan before and during the 18-month switch to Flint River water'. Together they form a unique fingerprint.

Cite this