Analysis of cerebrospinal fluid from chronic fatigue syndrome patients for multiple human ubiquitous viruses and xenotropic murine leukemia-related virus

Steven E. Schutzer, Megan A. Rounds, Benjamin H. Natelson, David J. Ecker, Mark W. Eshoo

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Recent reports showed many patients with chronic fatigue syndrome (CFS) harbor a retrovirus, xenotropic murine leukemia-related virus (XMRV), in blood; other studies could not replicate this finding. A useful next step would be to examine cerebrospinal fluid, because in some patients CFS is thought to be a brain disorder. Finding a microbe in the central nervous system would have greater significance than in blood because of the integrity of the blood-brain barrier. We examined cerebrospinal fluid from 43 CFS patients using polymerase chain reaction techniques, but did not find XMRV or multiple other common viruses, suggesting that exploration of other causes or pathogenetic mechanisms is warranted.

Original languageEnglish (US)
Pages (from-to)735-738
Number of pages4
JournalAnnals of Neurology
Volume69
Issue number4
DOIs
StatePublished - Mar 2011

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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