Analysis of Integrin Functions in Peri-Implantation Embryos, Hematopoietic System, and Skin

Eloi Montanez, Aleksandra Piwko-Czuchra, Martina Bauer, Shaohua Li, Peter Yurchenco, Reinhard Fässler

Research output: Chapter in Book/Report/Conference proceedingChapter

23 Scopus citations


Integrins mediate cell adhesion, permit traction forces important for cell migration, and cross-talk with growth factor receptors to regulate cell proliferation, cell survival, and cell differentiation. The plethora of functions explains their central role for development and disease. The progress in mouse genetics and the ease with which the mouse genome can be manipulated enormously contributed to our understanding of how integrins exert their functions at the molecular level. In the present chapter, we describe tests that are routinely used in our laboratory to investigate embryos, organs, and cells (peri-implantation embryos, hematopoietic system, epidermis, and hair follicles) that lack the expression of integrins or integrin-associated proteins.

Original languageEnglish (US)
Title of host publicationIntegrins
EditorsDavid Cheresh
Number of pages51
StatePublished - 2007

Publication series

NameMethods in Enzymology
ISSN (Print)0076-6879

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology


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