Animal models of post-traumatic stress disorder: Face validity

Sonal Goswami, Olga Rodríguez-Sierra, Michele Cascardi, Denis Paré

Research output: Contribution to journalReview articlepeer-review

85 Scopus citations

Abstract

Post-traumatic stress disorder (PTSD) is a debilitating condition that develops in a proportion of individuals following a traumatic event. Despite recent advances, ethical limitations associated with human research impede progress in understanding PTSD. Fortunately, much effort has focused on developing animal models to help study the pathophysiology of PTSD. Here, we provide an overview of animal PTSD models where a variety of stressors (physical, psychosocial, or psychogenic) are used to examine the long-term effects of severe trauma. We emphasize models involving predator threat because they reproduce human individual differences in susceptibility to, and in the long-term consequences of, psychological trauma.

Original languageEnglish (US)
Article numberArticle 89
JournalFrontiers in Neuroscience
Issue number7 MAY
DOIs
StatePublished - 2013

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Keywords

  • Animal model
  • Extinction
  • Post-traumatic stress disorder
  • Predator threat
  • Recognition memory

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