Anisotropic smoothing regularization (AnSR) in Thirion's Demons registration evaluates brain MRI tissue changes post-laser ablation

Eileen Hwuang, Shabbar Danish, Mirabela Rusu, Rachel Sparks, Robert Toth, Anant Madabhushi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

MRI-guided laser-induced interstitial thermal therapy (LITT) is a form of laser ablation and a potential alternative to craniotomy in treating glioblastoma multiforme (GBM) and epilepsy patients, but its effectiveness has yet to be fully evaluated. One way of assessing short-term treatment of LITT is by evaluating changes in post-treatment MRI as a measure of response. Alignment of pre- and post-LITT MRI in GBM and epilepsy patients via nonrigid registration is necessary to detect subtle localized treatment changes on imaging, which can then be correlated with patient outcome. A popular deformable registration scheme in the context of brain imaging is Thirion's Demons algorithm, but its flexibility often introduces artifacts without physical significance, which has conventionally been corrected by Gaussian smoothing of the deformation field. In order to prevent such artifacts, we instead present the Anisotropic smoothing regularizer (AnSR) which utilizes edge-detection and denoising within the Demons framework to regularize the deformation field at each iteration of the registration more aggressively in regions of homogeneously oriented displacements while simultaneously regularizing less aggressively in areas containing heterogeneous local deformation and tissue interfaces. In contrast, the conventional Gaussian smoothing regularizer (GaSR) uniformly averages over the entire deformation field, without carefully accounting for transitions across tissue boundaries and local displacements in the deformation field. In this work we employ AnSR within the Demons algorithm and perform pairwise registration on 2D synthetic brain MRI with and without noise after inducing a deformation that models shrinkage of the target region expected from LITT. We also applied Demons with AnSR for registering clinical T1-weighted MRI for one epilepsy and one GBM patient pre- and post-LITT. Our results demonstrate that by maintaining select displacements in the deformation field, AnSR outperforms both GaSR and no regularizer (NoR) in terms of normalized sum of squared differences (NSSD) with values such as 0.743, 0.807, and 1.000, respectively, for GBM.

Original languageEnglish (US)
Title of host publication2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
Pages4006-4009
Number of pages4
DOIs
StatePublished - Oct 31 2013
Externally publishedYes
Event2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 - Osaka, Japan
Duration: Jul 3 2013Jul 7 2013

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Other

Other2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
CountryJapan
CityOsaka
Period7/3/137/7/13

Fingerprint

Laser Therapy
Laser ablation
Magnetic resonance imaging
Brain
Tissue
Glioblastoma
Lasers
Hot Temperature
Epilepsy
Therapeutics
Artifacts
Imaging techniques
Edge detection
Craniotomy
Neuroimaging
Noise

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Hwuang, E., Danish, S., Rusu, M., Sparks, R., Toth, R., & Madabhushi, A. (2013). Anisotropic smoothing regularization (AnSR) in Thirion's Demons registration evaluates brain MRI tissue changes post-laser ablation. In 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 (pp. 4006-4009). [6610423] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC.2013.6610423
Hwuang, Eileen ; Danish, Shabbar ; Rusu, Mirabela ; Sparks, Rachel ; Toth, Robert ; Madabhushi, Anant. / Anisotropic smoothing regularization (AnSR) in Thirion's Demons registration evaluates brain MRI tissue changes post-laser ablation. 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013. 2013. pp. 4006-4009 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).
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Hwuang, E, Danish, S, Rusu, M, Sparks, R, Toth, R & Madabhushi, A 2013, Anisotropic smoothing regularization (AnSR) in Thirion's Demons registration evaluates brain MRI tissue changes post-laser ablation. in 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013., 6610423, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, pp. 4006-4009, 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013, Osaka, Japan, 7/3/13. https://doi.org/10.1109/EMBC.2013.6610423

Anisotropic smoothing regularization (AnSR) in Thirion's Demons registration evaluates brain MRI tissue changes post-laser ablation. / Hwuang, Eileen; Danish, Shabbar; Rusu, Mirabela; Sparks, Rachel; Toth, Robert; Madabhushi, Anant.

2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013. 2013. p. 4006-4009 6610423 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AU - Madabhushi, Anant

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Hwuang E, Danish S, Rusu M, Sparks R, Toth R, Madabhushi A. Anisotropic smoothing regularization (AnSR) in Thirion's Demons registration evaluates brain MRI tissue changes post-laser ablation. In 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013. 2013. p. 4006-4009. 6610423. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC.2013.6610423