Anterior uveitis associated with latanoprost

Robert D. Fechtner, Albert Khouri, Thom J. Zimmerman, John Bullock, Robert Feldman, Prasad Kulkarni, Andrew J. Michael, Tony Realini, Ronald Warwar

Research output: Contribution to journalArticlepeer-review

142 Scopus citations

Abstract

PURPOSE: To report the association of anterior uveitis with the use of latanoprost. METHODS: We studied four patients with complicated open-angle glaucoma who had anterior uveitis associated with the use of latanoprost. The uveitis was unilateral and occurred only in the eye receiving latanoprost in three patients. In one patient, latanoprost was used in both eyes, and the uveitis was bilateral. Four of five eyes had a history of prior inflammation and/or prior incisional surgery. All patients were rechallenged with the drug. RESULTS: The uveitis improved after cessation of latanoprost with or without topical corticosteroids. It recurred after rechallenging with latanoprost in all eyes. CONCLUSION: There is a possible association between latanoprost and anterior uveitis. Topical prostaglandin analogs may be relatively contraindicated in patients with a history of uveitis or prior ocular surgery. This association may also be possible in eyes that have not had previous uveitis or incisional surgery.

Original languageEnglish (US)
Pages (from-to)37-41
Number of pages5
JournalAmerican journal of ophthalmology
Volume126
Issue number1
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Ophthalmology

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