Anthocyanins and cancer prevention

Rasika Hudlikar, Renyi Wu, David Cheng, Dina Hsiao-Chen Kuo, Lujing Wang, Rebecca Peter, Ran Yin, Shanyi Li, Ah Ng Kong

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Anthocyanins are a class of water-soluble flavonoids, which give the intense color to many fruits and vegetables, such as blueberries and red cabbages. Recent studies have shown that anthocyanins have a range of pharmacological properties, such as prevention of cardiovascular disease, improvement of visual functions, obesity control, and anticancer activity. Their potential anticancer effects are reported to be based on a wide variety of biological activities including antioxidative stress; anti-inflammation; anti-mutagenesis; induction of differentiation; inhibition of proliferation; cell cycle arrest and apoptosis; anti-invasion; anti-metastasis; anti-angiogenesis and sensitizing cancer cells to chemotherapy. This chapter summarizes the latest developments on the anticancer activities of anthocyanins and anthocyanin-rich extracts in cell culture models, animal cancer models and some clinical trials. Their chemical structures, molecular mechanisms of action in cancer prevention, and in vivo pharmacokinetics-pharmacodynamics (PK-PD) properties will also be discussed.

Original languageEnglish (US)
Title of host publicationNatural Products for Cancer Chemoprevention
Subtitle of host publicationSingle Compounds and Combinations
PublisherSpringer International Publishing
Pages351-373
Number of pages23
ISBN (Electronic)9783030398552
ISBN (Print)9783030398545
DOIs
StatePublished - Jan 1 2020

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Keywords

  • Anthocyanidins
  • Anthocyanins
  • Antiinflammatory
  • Cancer prevention
  • Cellular signaling
  • Cyanidin
  • Delphinidin
  • Flavonoids
  • Malvidin
  • Nrf2-mediated antioxidative stress
  • Pharmacokinetics (PK)/pharmacodynamics (PD)

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