Anthocyanins and cancer prevention

Rasika Hudlikar, Renyi Wu, David Cheng, Dina Hsiao-Chen Kuo, Lujing Wang, Rebecca Peter, Ran Yin, Shanyi Li, Ah Ng Kong

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Anthocyanins are a class of water-soluble flavonoids, which give the intense color to many fruits and vegetables, such as blueberries and red cabbages. Recent studies have shown that anthocyanins have a range of pharmacological properties, such as prevention of cardiovascular disease, improvement of visual functions, obesity control, and anticancer activity. Their potential anticancer effects are reported to be based on a wide variety of biological activities including antioxidative stress; anti-inflammation; anti-mutagenesis; induction of differentiation; inhibition of proliferation; cell cycle arrest and apoptosis; anti-invasion; anti-metastasis; anti-angiogenesis and sensitizing cancer cells to chemotherapy. This chapter summarizes the latest developments on the anticancer activities of anthocyanins and anthocyanin-rich extracts in cell culture models, animal cancer models and some clinical trials. Their chemical structures, molecular mechanisms of action in cancer prevention, and in vivo pharmacokinetics-pharmacodynamics (PK-PD) properties will also be discussed.

Original languageEnglish (US)
Title of host publicationNatural Products for Cancer Chemoprevention
Subtitle of host publicationSingle Compounds and Combinations
PublisherSpringer International Publishing
Number of pages23
ISBN (Electronic)9783030398552
ISBN (Print)9783030398545
StatePublished - Jan 1 2020

All Science Journal Classification (ASJC) codes

  • Medicine(all)


  • Anthocyanidins
  • Anthocyanins
  • Antiinflammatory
  • Cancer prevention
  • Cellular signaling
  • Cyanidin
  • Delphinidin
  • Flavonoids
  • Malvidin
  • Nrf2-mediated antioxidative stress
  • Pharmacokinetics (PK)/pharmacodynamics (PD)


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