Anti-Diabetic Agents from Leaves of Combretum micranthum (Kinkeliba)

James Simon (Inventor)

Research output: Innovation

Abstract

At 40 and 80 min. following oral glucose challenge, the TPFA treated group had significantly lowered plasma glucose concentrations compared to the control group.


Invention Summary:

Rutgers scientists have developed a proprietary method of extracting and purifying a novel type of piperidine flavan alkaloids from the leaves of Combretum micranthum (kinkeliba) and a procedure for the preparation of total piperidine flavan alkaloids (TPFA) that possess anti-diabetic properties.

Kinkeliba is a highly regarded medicinal plant in Africa, with roots, bark, fruit and leaves being used. In its native Sub-Saharan Africa, the fresh and brewed leaves of kinkeliba have a long established history as being safe multi-functional agents that are consumed regularly for a broad range of health, prophylactic, curative, and anti-disease benefits. Kinkeliba herbal teas are a readily available niche specialty consumer product.

Our scientists have identified and isolated specific compounds from kinkeliba leaves that result in a significant glucose-lowering functionality and can be administered in efficacious dosages as a dietary supplement or food additive. Animal studies have shown that the isolated compounds:

  • decrease fasting plasma glucose levels
  • increase glucose tolerance
  • lower plasma insulin levels, and
  • decrease liver expression of the PEPCK gene, which indicates antidiabetic activity

Further experiments have demonstrated an anti-inflammatory action of the compounds. An effective preparation method has also been developed.

Market Applications:

  • Diabetes, metabolic disorders, weight loss, diuretics
  • Can be blended into existing formulations (food, beverage, or nutraceutical) to boost efficacy and broaden application and efficacy profile

Advantages:

  • Kinkeliba tea has a well documented traditional and safe medicinal use
  • Established safety profile
  • Readily available source
  • Rich in potent antioxidants
  • Distinct attributes and functionality as compared to other common tea (e.g., green tea or black tea) derivatives

Intellectual Property & Development Status:

US 8,642,769

Original languageEnglish (US)
StatePublished - Aug 2018

Fingerprint

Combretum
Tea
Glucose
Alkaloids
Dietary Supplements
Intellectual Property
Food and Beverages
Food Additives
Africa South of the Sahara
Medicinal Plants
Diuretics
Hypoglycemic Agents
Weight Loss
Fasting
Fruit
Anti-Inflammatory Agents
Antioxidants
History
Insulin
Safety

Keywords

  • Beverage
  • Diabetes
  • Metabolic disorders
  • weight loss

Cite this

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title = "Anti-Diabetic Agents from Leaves of Combretum micranthum (Kinkeliba)",
abstract = "At 40 and 80 min. following oral glucose challenge, the TPFA treated group had significantly lowered plasma glucose concentrations compared to the control group. Invention Summary: Rutgers scientists have developed a proprietary method of extracting and purifying a novel type of piperidine flavan alkaloids from the leaves of Combretum micranthum (kinkeliba) and a procedure for the preparation of total piperidine flavan alkaloids (TPFA) that possess anti-diabetic properties. Kinkeliba is a highly regarded medicinal plant in Africa, with roots, bark, fruit and leaves being used. In its native Sub-Saharan Africa, the fresh and brewed leaves of kinkeliba have a long established history as being safe multi-functional agents that are consumed regularly for a broad range of health, prophylactic, curative, and anti-disease benefits. Kinkeliba herbal teas are a readily available niche specialty consumer product. Our scientists have identified and isolated specific compounds from kinkeliba leaves that result in a significant glucose-lowering functionality and can be administered in efficacious dosages as a dietary supplement or food additive. Animal studies have shown that the isolated compounds: decrease fasting plasma glucose levels increase glucose tolerance lower plasma insulin levels, and decrease liver expression of the PEPCK gene, which indicates antidiabetic activity Further experiments have demonstrated an anti-inflammatory action of the compounds. An effective preparation method has also been developed. Market Applications: Diabetes, metabolic disorders, weight loss, diuretics Can be blended into existing formulations (food, beverage, or nutraceutical) to boost efficacy and broaden application and efficacy profile Advantages: Kinkeliba tea has a well documented traditional and safe medicinal use Established safety profile Readily available source Rich in potent antioxidants Distinct attributes and functionality as compared to other common tea (e.g., green tea or black tea) derivatives Intellectual Property & Development Status: US 8,642,769",
keywords = "Beverage, Diabetes, Metabolic disorders, weight loss",
author = "James Simon",
year = "2018",
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AU - Simon, James

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N2 - At 40 and 80 min. following oral glucose challenge, the TPFA treated group had significantly lowered plasma glucose concentrations compared to the control group. Invention Summary: Rutgers scientists have developed a proprietary method of extracting and purifying a novel type of piperidine flavan alkaloids from the leaves of Combretum micranthum (kinkeliba) and a procedure for the preparation of total piperidine flavan alkaloids (TPFA) that possess anti-diabetic properties. Kinkeliba is a highly regarded medicinal plant in Africa, with roots, bark, fruit and leaves being used. In its native Sub-Saharan Africa, the fresh and brewed leaves of kinkeliba have a long established history as being safe multi-functional agents that are consumed regularly for a broad range of health, prophylactic, curative, and anti-disease benefits. Kinkeliba herbal teas are a readily available niche specialty consumer product. Our scientists have identified and isolated specific compounds from kinkeliba leaves that result in a significant glucose-lowering functionality and can be administered in efficacious dosages as a dietary supplement or food additive. Animal studies have shown that the isolated compounds: decrease fasting plasma glucose levels increase glucose tolerance lower plasma insulin levels, and decrease liver expression of the PEPCK gene, which indicates antidiabetic activity Further experiments have demonstrated an anti-inflammatory action of the compounds. An effective preparation method has also been developed. Market Applications: Diabetes, metabolic disorders, weight loss, diuretics Can be blended into existing formulations (food, beverage, or nutraceutical) to boost efficacy and broaden application and efficacy profile Advantages: Kinkeliba tea has a well documented traditional and safe medicinal use Established safety profile Readily available source Rich in potent antioxidants Distinct attributes and functionality as compared to other common tea (e.g., green tea or black tea) derivatives Intellectual Property & Development Status: US 8,642,769

AB - At 40 and 80 min. following oral glucose challenge, the TPFA treated group had significantly lowered plasma glucose concentrations compared to the control group. Invention Summary: Rutgers scientists have developed a proprietary method of extracting and purifying a novel type of piperidine flavan alkaloids from the leaves of Combretum micranthum (kinkeliba) and a procedure for the preparation of total piperidine flavan alkaloids (TPFA) that possess anti-diabetic properties. Kinkeliba is a highly regarded medicinal plant in Africa, with roots, bark, fruit and leaves being used. In its native Sub-Saharan Africa, the fresh and brewed leaves of kinkeliba have a long established history as being safe multi-functional agents that are consumed regularly for a broad range of health, prophylactic, curative, and anti-disease benefits. Kinkeliba herbal teas are a readily available niche specialty consumer product. Our scientists have identified and isolated specific compounds from kinkeliba leaves that result in a significant glucose-lowering functionality and can be administered in efficacious dosages as a dietary supplement or food additive. Animal studies have shown that the isolated compounds: decrease fasting plasma glucose levels increase glucose tolerance lower plasma insulin levels, and decrease liver expression of the PEPCK gene, which indicates antidiabetic activity Further experiments have demonstrated an anti-inflammatory action of the compounds. An effective preparation method has also been developed. Market Applications: Diabetes, metabolic disorders, weight loss, diuretics Can be blended into existing formulations (food, beverage, or nutraceutical) to boost efficacy and broaden application and efficacy profile Advantages: Kinkeliba tea has a well documented traditional and safe medicinal use Established safety profile Readily available source Rich in potent antioxidants Distinct attributes and functionality as compared to other common tea (e.g., green tea or black tea) derivatives Intellectual Property & Development Status: US 8,642,769

KW - Beverage

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KW - Metabolic disorders

KW - weight loss

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