Anti-GM1 IgA antibodies in Guillain-Barré syndrome

Amjad Ilyas; Francis A. Mithen; Zi Wei Chen; Stuart D. Cook

doi:10.1016/0165-5728(92)90031-F

Anti-G_M1 IgA antibodies in Guillain-Barré syndrome

Amjad Ilyas, Francis A. Mithen, Zi Wei Chen, Stuart D. Cook

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Serum anti-G_M1 IgA antibodies were detected in 15 of 53 (28%) patients with the acute Guillain-Barré syndrome (GBS) and in one of 26 (4%) patients with other neurological diseases. Although nine GBS patients had anti-G_M1 IgA titers of 1 : 200 or less, six patients had titers of 1 : 800 or more. Some GBS patients with anti-G_M1 IgA antibodies also had antibodies against G_D1b or G_M2 or both. The presence of markedly elevated anti-G_M1 IgA was associated with a poor clinical outcome at 6 and 12 months following onset of the GBS. The possible pathogenetic role of anti-G_M1 IgA antibodies remains to be established.

Original language	English (US)
Pages (from-to)	69-76
Number of pages	8
Journal	Journal of Neuroimmunology
Volume	36
Issue number	1
DOIs	https://doi.org/10.1016/0165-5728(92)90031-F
State	Published - Jan 1 1992

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

Keywords

Enzyme-linked immunosorbent assay
G ganglioside
Guillain-Barré syndrome
Immunoglobulin A
Thin-layer chromatogram-overlay technique

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10.1016/0165-5728(92)90031-F

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abstract = "Serum anti-GM1 IgA antibodies were detected in 15 of 53 (28%) patients with the acute Guillain-Barr{\'e} syndrome (GBS) and in one of 26 (4%) patients with other neurological diseases. Although nine GBS patients had anti-GM1 IgA titers of 1 : 200 or less, six patients had titers of 1 : 800 or more. Some GBS patients with anti-GM1 IgA antibodies also had antibodies against GD1b or GM2 or both. The presence of markedly elevated anti-GM1 IgA was associated with a poor clinical outcome at 6 and 12 months following onset of the GBS. The possible pathogenetic role of anti-GM1 IgA antibodies remains to be established.",

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AU - Ilyas, Amjad

AU - Mithen, Francis A.

AU - Chen, Zi Wei

AU - Cook, Stuart D.

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N2 - Serum anti-GM1 IgA antibodies were detected in 15 of 53 (28%) patients with the acute Guillain-Barré syndrome (GBS) and in one of 26 (4%) patients with other neurological diseases. Although nine GBS patients had anti-GM1 IgA titers of 1 : 200 or less, six patients had titers of 1 : 800 or more. Some GBS patients with anti-GM1 IgA antibodies also had antibodies against GD1b or GM2 or both. The presence of markedly elevated anti-GM1 IgA was associated with a poor clinical outcome at 6 and 12 months following onset of the GBS. The possible pathogenetic role of anti-GM1 IgA antibodies remains to be established.

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