@article{aa731b4cd1f84f94843d7d2fba9c3bc7,
title = "Anti-inflammatory and immunosuppressive compounds from Tripterygium wilfordii",
abstract = "The extract of Tripterygium wilfordii Hook F. (TwHF), which showed anti-inflammatory and immunosuppressive activities in human clinical trials for rheumatoid arthritis, was subjected to the activity-guided fractionation and spectroscopic characterization of bioactives. A tetrahydrofuran lignan, tripterygiol (1), and eight known compounds, all capable of suppressing pro-inflammatory gene expression were identified. Most of the pharmacological activity of the extract can be attributed to triptolide, its most abundant and active component, with some contribution from tripdiolide.",
keywords = "Anti-inflammation, Celastraceae, Cyclooxygenase-2 (COX-2), Immunosuppression, Inducible nitric oxide synthase (iNOS), Interleukin-1β (IL-1β), Polymerase chain reaction (PCR), Tetrahydrofuran lignan, Tripdiolide, Tripterygium wilfordii, Triptolide",
author = "Jun Ma and Moul Dey and Hui Yang and Alexander Poulev and Reneta Pouleva and Ruth Dorn and Lipsky, {Peter E.} and Kennelly, {Edward J.} and Ilya Raskin",
note = "Funding Information: We thank Drs. Longqin Hu, Joseph E. Rice, Xiaolin Fu, and Jingzhi Tian, and Ms. Suzanne G. Rzuczek for assistance with optical rotations; HRESIMS were obtained from the Mass Spectrometry Laboratory, School of Chemical Sciences, University of Illinois at Urbana-Champaign, and their Q-TOF Ultima spectrometer was purchased in part with a grant from the National Science Foundation, Division of Biological Infrastructure (DBI-0100085). Research supported by Phytomedics Inc. (Jamesburg NJ, USA). Additional funding provided by the NIH Center for Dietary Supplements Research on Botanicals and Metabolic Syndrome, grant # 1-P50 AT002776-01; Fogarty International Center of the NIH under U01 TW006674 for the International Cooperative Biodiversity Groups; and Rutgers University & NJ Agricultural Experiment Station. ",
year = "2007",
month = apr,
doi = "10.1016/j.phytochem.2007.02.021",
language = "English (US)",
volume = "68",
pages = "1172--1178",
journal = "Phytochemistry",
issn = "0031-9422",
publisher = "Elsevier Ltd",
number = "8",
}