Anti-inflammatory and immunosuppressive compounds from Tripterygium wilfordii

Jun Ma, Moul Dey, Hui Yang, Alexander Poulev, Reneta Pouleva, Ruth Dorn, Peter E. Lipsky, Edward J. Kennelly, Ilya Raskin

Research output: Contribution to journalArticlepeer-review

130 Scopus citations

Abstract

The extract of Tripterygium wilfordii Hook F. (TwHF), which showed anti-inflammatory and immunosuppressive activities in human clinical trials for rheumatoid arthritis, was subjected to the activity-guided fractionation and spectroscopic characterization of bioactives. A tetrahydrofuran lignan, tripterygiol (1), and eight known compounds, all capable of suppressing pro-inflammatory gene expression were identified. Most of the pharmacological activity of the extract can be attributed to triptolide, its most abundant and active component, with some contribution from tripdiolide.

Original languageEnglish (US)
Pages (from-to)1172-1178
Number of pages7
JournalPhytochemistry
Volume68
Issue number8
DOIs
StatePublished - Apr 2007

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

Keywords

  • Anti-inflammation
  • Celastraceae
  • Cyclooxygenase-2 (COX-2)
  • Immunosuppression
  • Inducible nitric oxide synthase (iNOS)
  • Interleukin-1β (IL-1β)
  • Polymerase chain reaction (PCR)
  • Tetrahydrofuran lignan
  • Tripdiolide
  • Tripterygium wilfordii
  • Triptolide

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