Anti-inflammatory effects of a sesquiterpene lactone extract from chicory (Cichorium intybus L.) Roots

Christophe Ripoll, Barbara M. Schmidt, Nebojsa Ilic, Alexander Poulev, Moul Dey, Anvar G. Kurmukov, Ilya Raskin

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

A chicory root extract rich in sesquiterpene lactones significantly reduced inflammation in two animal models. In a rat paw edema model, chicory extract at 50 and 100 mg/kg significantly reduced inflammation by 58 and 76%, respectively, 24 h after carrageenan injection. In a mouse collagen induced arthritis model, chicory extract (200 mg/kg) reduced paw edema by 71% while the extract was being administered, and 31% 48 h after extract administration was discontinued. Two possible modes of action were investigated, pro-inflammatory gene expression and nitric oxide production by LPS-elicited macrophages. Chicory root extract down-regulated COX-2, TNF-a, IL 1β, and iNOS expression and reduced nitric oxide production in a dose dependant manner. Several compounds were isolated from the chicory extract and tested in vitro to confirm activity. Dihydrolactucopicrin and 8-deoxylactucin showed particularly high nitric oxide inhibitory activity (1C50 = 13 uM for both). Dihydrolactucopicrin also was shown to down-regulate pro-inflammatory gene expression. These data demonstrate that chicory extracts rich in sesquiterpene lactones have potent anti-inflammatory activity with potential therapeutic use.

Original languageEnglish (US)
Pages (from-to)717-722
Number of pages6
JournalNatural Product Communications
Volume2
Issue number7
DOIs
StatePublished - 2007

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

Keywords

  • 8-deoxylactucin
  • Chicory
  • Cichorium intybus
  • Dihydrolactucopicrin
  • Inflammation
  • Sesquiterpene lactones

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