Anti-inflammatory effects of newly synthesized α-galacto-oligosaccharides on dextran sulfate sodium-induced colitis in C57BL/6J mice

Zhuqing Dai, Simin Feng, Anna Liu, Hong Wang, Xiaoxiong Zeng, Chung S. Yang

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

α-Galacto-oligosaccharides have been reported to have beneficial health effects. The purpose of this study was to investigate the preventive effects of a newly synthesized α-galacto-oligosaccharide mixture (α-GOSg), as well as raffinose family oligosaccharides (RFOs), on dextran sulfate sodium (DSS)-induced colitis in mice. When administered in drinking water at 0.5% for 15 days, both α-GOSg and RFOs significantly decreased fecal hemoglobin content, partially prevented colon length shortening, reduced the severity of colon inflammation, and attenuated DSS-induced upregulation of cyclooxygenase-2. In addition, the activation of the inflammatory regulator nuclear factor-kappa B was slightly inhibited by α-GOSg. The results showed that the newly synthesized α-GOSg preparation has similar anti-inflammatory activities as RFOs in this colitis model. The anti-inflammatory activity of α-GOSg in humans remains to be investigated.

Original languageEnglish (US)
Pages (from-to)350-357
Number of pages8
JournalFood Research International
Volume109
DOIs
StatePublished - Jul 2018

All Science Journal Classification (ASJC) codes

  • Food Science

Keywords

  • Anti-inflammatory
  • Colitis
  • Cyclooxygenase-2
  • α-GOSg

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