@article{0dd58f934bc74ae1bf9fb9db00823816,
title = "Anti-inflammatory effects of newly synthesized α-galacto-oligosaccharides on dextran sulfate sodium-induced colitis in C57BL/6J mice",
abstract = "α-Galacto-oligosaccharides have been reported to have beneficial health effects. The purpose of this study was to investigate the preventive effects of a newly synthesized α-galacto-oligosaccharide mixture (α-GOSg), as well as raffinose family oligosaccharides (RFOs), on dextran sulfate sodium (DSS)-induced colitis in mice. When administered in drinking water at 0.5% for 15 days, both α-GOSg and RFOs significantly decreased fecal hemoglobin content, partially prevented colon length shortening, reduced the severity of colon inflammation, and attenuated DSS-induced upregulation of cyclooxygenase-2. In addition, the activation of the inflammatory regulator nuclear factor-kappa B was slightly inhibited by α-GOSg. The results showed that the newly synthesized α-GOSg preparation has similar anti-inflammatory activities as RFOs in this colitis model. The anti-inflammatory activity of α-GOSg in humans remains to be investigated.",
keywords = "Anti-inflammatory, Colitis, Cyclooxygenase-2, α-GOSg",
author = "Zhuqing Dai and Simin Feng and Anna Liu and Hong Wang and Xiaoxiong Zeng and Yang, {Chung S.}",
note = "Funding Information: This work was supported by grants from the U.S. National Institutes of Health (CA120915 and shared facilities funded by CA72720 and ES05022), the John L. Colaizzi Chair Endowment fund, Grants-in-Aid for scientific research from the National Natural Science Foundation of China (31171750), and a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD). The authors thank the personnel of Laboratory Animal Service for taking care of our research mice, and thank Ms. Vi P. Dan for assistance in the preparation of this manuscript. Funding Information: This work was supported by grants from the U.S. National Institutes of Health ( CA120915 and shared facilities funded by CA72720 and ES05022 ), the John L. Colaizzi Chair Endowment fund, Grants-in-Aid for scientific research from the National Natural Science Foundation of China ( 31171750 ), and a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD). The authors thank the personnel of Laboratory Animal Service for taking care of our research mice, and thank Ms. Vi P. Dan for assistance in the preparation of this manuscript. Appendix A Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",
year = "2018",
month = jul,
doi = "10.1016/j.foodres.2018.04.054",
language = "English (US)",
volume = "109",
pages = "350--357",
journal = "Food Research International",
issn = "0963-9969",
publisher = "Elsevier Limited",
}