Antibiotic treatment of small intestinal bacterial overgrowth: What is the evidence?

Emily Schwartz, Luigi Brunetti, Jane Ziegler

Research output: Contribution to journalReview article

Abstract

Small intestinal bacterial overgrowth (SIBO) is characterized by an abnormally high concentration of bacteria in the small bowel, and is often associated with abdominal pain, bloating, and/or stool changes. Antibiotics, prebiotics, and probiotics have been considered as treatment options for individuals with SIBO. The aim of this literature review was to evaluate the evidence supporting antibiotic therapy for SIBO treatment. A systematic search of PubMed, Cochrane Library, and Web of Science databases was performed, and 13 studies were included for analysis. The analysis of the available data suggests that antibiotics, particularly rifaximin, may be effective in normalizing breath tests and improving gastrointestinal symptoms in patients with SIBO.

Original languageEnglish (US)
Pages (from-to)296-313
Number of pages18
JournalTopics in Clinical Nutrition
Volume31
Issue number4
DOIs
StatePublished - Oct 1 2016

Fingerprint

Anti-Bacterial Agents
rifaximin
Library Science
Prebiotics
Breath Tests
Probiotics
PubMed
Abdominal Pain
Therapeutics
Databases
Bacteria

All Science Journal Classification (ASJC) codes

  • Nutrition and Dietetics

Keywords

  • Antibiotics
  • Metronidazole
  • Prebiotics
  • Probiotics
  • Rifaximin
  • Small Intestinal Bacterial Overgrowth

Cite this

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Antibiotic treatment of small intestinal bacterial overgrowth : What is the evidence? / Schwartz, Emily; Brunetti, Luigi; Ziegler, Jane.

In: Topics in Clinical Nutrition, Vol. 31, No. 4, 01.10.2016, p. 296-313.

Research output: Contribution to journalReview article

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