Antifungal action of amphotericin B in combination with other polyene or imidazole antibiotics

J. Brajtburg, D. Kobayashi, G. Medoff, G. S. Kobayashi

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

We compared the in vitro antifungal action of amphotericin B (AmB) used alone or in combination with a second polyene antibiotic or with miconazole or ketoconazole. When AmB was used in combination with either filipin or Etruscomycin® (Farmitalia, Milan, Italy), antagonism or potentiation of the antifungal effect against Candida albicans resulted. Addition of AmB to Etruscomycin- or filipin-treated cultures resulted in antagonism. In contrast, potentiation occurred when Etruscomycin or filipin was added to cultures treated with AmB. The outcome of incubating C. albicans with combinations of AmB and either miconazole or ketonazole depended on the duration of exposure of the cells to the drugs. Short-term incubations resulted in antagonism, whereas potentiation of antifungal effects occurred after prolonged exposure of cells to the antibiotics. In addition, supplementation of cultures with serum protein-potentiated AmB induced K+ leakage at low protein concentration and inhibited K+ leakage at high protein concentrations.

Original languageEnglish (US)
Pages (from-to)138-146
Number of pages9
JournalJournal of Infectious Diseases
Volume146
Issue number2
DOIs
StatePublished - 1982
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

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