Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Each year, fungi are responsible for millions of superficial and systemic infections that all require effective antifungal therapy. After more than six decades of development, existing antifungal agents represent relatively few targets and chemical classes, which include agents that alter membrane function (azole and polyene), cell wall structure (echinocandin) and DNA and protein synthesis (pyrimidine analog). Overall, these agents display a range of chemical spectrum, pharmacokinetics and pharmacodynamics, toxicity and bioavailability. A new generation of agents is needed to overcome some chemical limitations and meet the challenges posed by expanding prophylaxis and empiric therapy along with selection of drug resistant strains. The challenging history of antifungal development serves as a foundation for new discovery.

Original languageEnglish (US)
Title of host publicationCandida albicans
Subtitle of host publicationCellular and Molecular Biology: Second Edition
PublisherSpringer International Publishing
Number of pages19
ISBN (Electronic)9783319504094
ISBN (Print)9783319504087
StatePublished - Jan 31 2017

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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