Antigenic changes during intracellular differentiation of Leishmania mexicana in cultured macrophages

K. P. Chang, D. Fong

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Antigenic changes during the intracellular transformation of Leishmania mexicana subsp. amazonensis from promastigotes to amastigotes in macrophage of J774G8 line were noted mostly among protein bands of 24 to 68 kilodaltons in apparent molecular weight. In this region, six were identified as common antigens of both stages, six to seven were identified as promastigote specific, and three to five were identified as amastigote specific. At the higher-molecular-weight region (>68 kilodalton) were two bands, one being predominant in amastigotes and the other in promastigotes. There may be a transformation-specific band (apparent molecular weight = 20 kilodaltons). The transition of these stage-specific antigens varies considerably with different protein species and may play important roles in intracellular leishmanial differentiation.

Original languageEnglish (US)
Pages (from-to)430-431
Number of pages2
JournalInfection and immunity
Volume36
Issue number1
DOIs
StatePublished - 1982
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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