Antihyperglycemic activity of Tarralin™, an ethanolic extract of Artemisia dracunculus L.

D. M. Ribnicky, A. Poulev, M. Watford, W. T. Cefalu, I. Raskin

Research output: Contribution to journalArticlepeer-review

103 Scopus citations

Abstract

The studies reported here were undertaken to examine the antihyperglycemic activity of an ethanolic extract of Artemisia dracunculus L., called Tarralin™ in diabetic and non-diabetic animals. In genetically diabetic KK-Aγ mice, Tarralin™ treatment by gavage (500 mg/kg body wt./day for 7 days) lowered elevated blood glucose levels by 24% from 479±25 to 352±16 mg/dl relative to control animals. In comparison, treatment with the known antidiabetic drugs, troglitazone (30 mg/kg body wt./day) and metformin (300 mg/kg body wt./day), decreased blood glucose concentrations by 28% and 41%, respectively. Blood insulin concentrations were reduced in the KK-Aγ mice by 33% with Tarralin™, 48% with troglitazone and 52% with metformin. In (STZ)-induced diabetic mice, Tarralin™ treatment, (500 mg/kg body wt./day for 7 days), also significantly lowered blood glucose concentrations, by 20%, from 429±41 to 376±58 mg/dl relative to control. As a possible mechanism, Tarralin™ was shown to significantly decrease phosphoenolpyruvate carboxykinase (PEPCK) mRNA expression by 28% in STZ-induced diabetic rats. In non-diabetic animals, treatment with Tarralin™ did not significantly alter PEPCK expression, blood glucose or insulin concentrations. The extract was also shown to increase the binding of glucagon-like peptide (GLP-1) to its receptor in vitro. These results indicate that Tarralin™ has antihyperglycemic activity and a potential role in the management of diabetic states.

Original languageEnglish (US)
Pages (from-to)550-557
Number of pages8
JournalPhytomedicine
Volume13
Issue number8
DOIs
StatePublished - Sep 11 2006

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

Keywords

  • Antidiabetic
  • Artemisia dracunculus
  • Blood glucose
  • Diabetes
  • GLP-1
  • Hyperglycemia
  • Hypoglycemia
  • PEPCK
  • Russian tarragon

Fingerprint Dive into the research topics of 'Antihyperglycemic activity of Tarralin™, an ethanolic extract of Artemisia dracunculus L.'. Together they form a unique fingerprint.

Cite this