Antihypertensives. 1. Syntheses of Thiazino-, Thiazepino-, and Thiazoninoethylguanidines

Lawrence D. Wise, Glenn C. Morrison, Katherine Egan, Michael A. Commarato, Gregory Kopia, Edmund C. Lattime

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The discovery of guanethidine1 has generated considerable interest in compounds which exert their antihypertensive effects by blockade of the adrenergic neurone. Subsequent structure-activity studies have demonstrated that the azocino ring of guanethidine can be altered without loss of antihypertensive activity.2 The results of modification of the heterocyclic ring by incorporation of a sulfur atom are described in this paper. Two approaches were selected-insertion of the sulfur atom directly into the ring, guanidines 1 and 2, and bridging of the ring with a sulfur atom, guanidine 3.

Original languageEnglish (US)
Pages (from-to)1232-1234
Number of pages3
JournalJournal of medicinal chemistry
Issue number11
StatePublished - Nov 1 1974
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery


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