Antileukemic Alkaloids from Taxus wallichiana Zucc

Roger W. Miller, Richard G. Powell, Cecil R. Smith, Edward Arnold, Jon Clardy

Research output: Contribution to journalArticle

197 Scopus citations

Abstract

A new antileukemic taxane alkaloid, cephalomannine (la), has been isolated from leaves, stems, and roots of Taxus wallichiana Zucc. Cephalomannine is closely related to taxol (lb), a previously characterized antileukemic alkaloid, which also occurs in T. wallichiana but in lesser amounts them cephalomannine. The new alkaloid and its hydrolysis products were characterized by nucleetr magnetic resonance, mass spectroscopy, and X-ray crystallography; taxol and two cytotoxic taxeme congeners were also identified.

Original languageEnglish (US)
Pages (from-to)1469-1474
Number of pages6
JournalJournal of Organic Chemistry
Volume46
Issue number7
DOIs
StatePublished - Mar 1981
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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    Miller, R. W., Powell, R. G., Smith, C. R., Arnold, E., & Clardy, J. (1981). Antileukemic Alkaloids from Taxus wallichiana Zucc. Journal of Organic Chemistry, 46(7), 1469-1474. https://doi.org/10.1021/jo00320a045