Antimicrobial activity of various 4- and 5-substituted 1-phenylnaphthalenes

Cody Kelley, Songfeng Lu, Ajit Parhi, Malvika Kaul, Daniel S. Pilch, Edmond J. Lavoie

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Bacterial cell division occurs in conjunction with the formation of a cytokinetic Z-ring structure comprised of FtsZ subunits. Agents that can disrupt Z-ring formation have the potential, through this unique mechanism, to be effective against several of the newly emerging multi-drug resistant strains of infectious bacteria. 1- and 12-Aryl substituted benzo[c]phenanthridines have been identified as antibacterial agents that could exert their activity by disruption of Z-ring formation. Substituted 4- and 5-amino-1-phenylnaphthalenes represent substructures within the pharmacophore of these benzo[c] phenanthridines. Several 4- and 5-substituted 1-phenylnaphthalenes were synthesized and evaluated for antibacterial activity against Staphylococcus aureus and Enterococcus faecalis. The impact of select compounds on the polymerization dynamics of S. aureus FtsZ was also assessed.

Original languageEnglish (US)
Pages (from-to)395-409
Number of pages15
JournalEuropean Journal of Medicinal Chemistry
Volume60
DOIs
StatePublished - Feb 2013

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

Keywords

  • 1-Phenylnaphthalenes
  • Antibacterial
  • Enterococcus faecalis
  • FtsZ-targeting
  • Staphylococcus aureus

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