Antineoplastic activity of benzimidazo[1,2-b]-isoquinolines, indolo[2,3-b]quinolines, and pyridocarbazoles

Ronni L. Weinkauf, Allan Y. Chen, Chiang Yu, Leroy Liu, Louis Barrows, Edmond J. LaVoie

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Substituted pyrido[3,4-b]carbazoles, pyrido[2,3-b]carbazoles, indolo[2,3-b]quinolines, and benzimidazo[1,2-b]-isoquinolines were synthesized and evaluated for biological activity. Several methylated derivatives of these heterocyclic compounds had similar activity to ellipticine as mammalian topoisomerase II inhibitors. Methylated derivatives of these heterocyclic compounds were also highly active in vitro, inhibiting the growth of several human tumor cell lines. These data demonstrate that the antineoplastic activity associated with ellipticine can be retained within a wide variety of analogous heterocyclics.

Original languageEnglish (US)
Pages (from-to)781-786
Number of pages6
JournalBioorganic and Medicinal Chemistry
Volume2
Issue number8
DOIs
StatePublished - Aug 1994

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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