Antiplasmodial activity of twenty essential oils from malagasy aromatic plants

Michel Ratsimbason, Lalasoa Ranarivelo, H. Rodolfo Juliani, James E. Simon

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Abstract

In search for new plant-derived biologically active compounds against malaria parasites resistant to commercially available drugs, twenty essential oils extracted from Malagasy aromatic plants were assessed for their anti-plasmodial activity against the multi-drug-resistant strain of Plasmodium falciparum FCM29. The plants were subjected to steam distillation and the aromatic volatile oils captured using a Clevenger trap. Fourteen essential oils were active against Plasmodium falciparum in culture with IC50s ranging from 27-225 μg/mL. While the essential oils (Cymbopogon citratus and Lantana camara) showed activities similar to that of chloroquine, none exhibited the high activity as achieved by quinine.

Original languageEnglish (US)
Pages (from-to)209-215
Number of pages7
JournalACS Symposium Series
Volume1021
DOIs
Publication statusPublished - Dec 20 2009

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All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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