In search for new plant-derived biologically active compounds against malaria parasites resistant to commercially available drugs, twenty essential oils extracted from Malagasy aromatic plants were assessed for their anti-plasmodial activity against the multi-drug-resistant strain of Plasmodium falciparum FCM29. The plants were subjected to steam distillation and the aromatic volatile oils captured using a Clevenger trap. Fourteen essential oils were active against Plasmodium falciparum in culture with IC50s ranging from 27-225 μg/mL. While the essential oils (Cymbopogon citratus and Lantana camara) showed activities similar to that of chloroquine, none exhibited the high activity as achieved by quinine.
All Science Journal Classification (ASJC) codes
- Chemical Engineering(all)