Anti‐Rh39—A “New” Specificity Rh System Antibody

P. D. Issitt; B. G. Pavone; M. Shapiro

doi:10.1046/j.1537-2995.1979.19479250175.x

Anti‐Rh39—A “New” Specificity Rh System Antibody

P. D. Issitt, B. G. Pavone, M. Shapiro

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Two examples of an autoantibody that defines a hitherto unrecognized Rh system antigen are described. Both were produced by C‐negative individuals and ostensibly resembled anti‐C in specificity. However, adsorption studies showed that the antigen that the autoantibodies define is present on all red blood cells with a “normal” Rh phenotype and on D—/D— and Dc‐/Dc‐ samples. The antigen detected is not present on Rh_null red blood cells. Serologic studies have shown that the new antibody, that has been named anti‐Rh39, has a different specificity from those that define the antigens C, Ce(rh₁), G, Hr_o, Hr, C^G, LW, Rh:29, Rh:34 and U. A possible relationship between auto‐anti‐Rh39 and alio‐anti‐C, in terms of the immune response, is discussed. 1979 AABB

Original language	English (US)
Pages (from-to)	389-397
Number of pages	9
Journal	Transfusion
Volume	19
Issue number	4
DOIs	https://doi.org/10.1046/j.1537-2995.1979.19479250175.x
State	Published - 1979
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Hematology

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10.1046/j.1537-2995.1979.19479250175.x

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title = "Anti‐Rh39—A “New” Specificity Rh System Antibody",

abstract = "Two examples of an autoantibody that defines a hitherto unrecognized Rh system antigen are described. Both were produced by C‐negative individuals and ostensibly resembled anti‐C in specificity. However, adsorption studies showed that the antigen that the autoantibodies define is present on all red blood cells with a “normal” Rh phenotype and on D—/D— and Dc‐/Dc‐ samples. The antigen detected is not present on Rhnull red blood cells. Serologic studies have shown that the new antibody, that has been named anti‐Rh39, has a different specificity from those that define the antigens C, Ce(rh1), G, Hro, Hr, CG, LW, Rh:29, Rh:34 and U. A possible relationship between auto‐anti‐Rh39 and alio‐anti‐C, in terms of the immune response, is discussed. 1979 AABB",

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AU - Issitt, P. D.

AU - Pavone, B. G.

AU - Shapiro, M.

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N2 - Two examples of an autoantibody that defines a hitherto unrecognized Rh system antigen are described. Both were produced by C‐negative individuals and ostensibly resembled anti‐C in specificity. However, adsorption studies showed that the antigen that the autoantibodies define is present on all red blood cells with a “normal” Rh phenotype and on D—/D— and Dc‐/Dc‐ samples. The antigen detected is not present on Rhnull red blood cells. Serologic studies have shown that the new antibody, that has been named anti‐Rh39, has a different specificity from those that define the antigens C, Ce(rh1), G, Hro, Hr, CG, LW, Rh:29, Rh:34 and U. A possible relationship between auto‐anti‐Rh39 and alio‐anti‐C, in terms of the immune response, is discussed. 1979 AABB

AB - Two examples of an autoantibody that defines a hitherto unrecognized Rh system antigen are described. Both were produced by C‐negative individuals and ostensibly resembled anti‐C in specificity. However, adsorption studies showed that the antigen that the autoantibodies define is present on all red blood cells with a “normal” Rh phenotype and on D—/D— and Dc‐/Dc‐ samples. The antigen detected is not present on Rhnull red blood cells. Serologic studies have shown that the new antibody, that has been named anti‐Rh39, has a different specificity from those that define the antigens C, Ce(rh1), G, Hro, Hr, CG, LW, Rh:29, Rh:34 and U. A possible relationship between auto‐anti‐Rh39 and alio‐anti‐C, in terms of the immune response, is discussed. 1979 AABB

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Anti‐Rh39—A “New” Specificity Rh System Antibody

Abstract

All Science Journal Classification (ASJC) codes

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