Antisense RNA: its functions and applications in gene regulation - a review

Masayori Inouye

doi:10.1016/0378-1119(88)90124-2

Antisense RNA: its functions and applications in gene regulation - a review

Masayori Inouye

Research output: Contribution to journal › Article › peer-review

175 Scopus citations

Abstract

All known antisense RNAs existing in nature are described. Of 11 natural antisense RNAs, nine function at the level of transcription and two at the level of DNA replication. On the basis of their inhibitory mechanisms they can be separated into three classes. From what can be found in the naturally occurring antisense RNAs, strategies in designing artificial antisense RNAs for gene expression are proposed, and applications and potential problems discussed.

Original language	English (US)
Pages (from-to)	25-34
Number of pages	10
Journal	Gene
Volume	72
Issue number	1-2
DOIs	https://doi.org/10.1016/0378-1119(88)90124-2
State	Published - Dec 10 1988

All Science Journal Classification (ASJC) codes

Genetics

Keywords

Natural anti-mRNA
design of artificial antisense RNA
inhibition of transcription
initiation of DNA replication
primers
recombinant DNA
ribosome binding
ribozyme

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10.1016/0378-1119(88)90124-2

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title = "Antisense RNA: its functions and applications in gene regulation - a review",

abstract = "All known antisense RNAs existing in nature are described. Of 11 natural antisense RNAs, nine function at the level of transcription and two at the level of DNA replication. On the basis of their inhibitory mechanisms they can be separated into three classes. From what can be found in the naturally occurring antisense RNAs, strategies in designing artificial antisense RNAs for gene expression are proposed, and applications and potential problems discussed.",

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author = "Masayori Inouye",

note = "Funding Information: The authort hanksK athy Takayamaf or her critical readingo f this manuscript. This work is supportedb y grantsf rom theA meri-can Cancer Society,E nzo BiochemI nc., and New Jersey Commissiono n Sciencea nd Technology.",

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N2 - All known antisense RNAs existing in nature are described. Of 11 natural antisense RNAs, nine function at the level of transcription and two at the level of DNA replication. On the basis of their inhibitory mechanisms they can be separated into three classes. From what can be found in the naturally occurring antisense RNAs, strategies in designing artificial antisense RNAs for gene expression are proposed, and applications and potential problems discussed.

AB - All known antisense RNAs existing in nature are described. Of 11 natural antisense RNAs, nine function at the level of transcription and two at the level of DNA replication. On the basis of their inhibitory mechanisms they can be separated into three classes. From what can be found in the naturally occurring antisense RNAs, strategies in designing artificial antisense RNAs for gene expression are proposed, and applications and potential problems discussed.

KW - Natural anti-mRNA

KW - design of artificial antisense RNA

KW - inhibition of transcription

KW - initiation of DNA replication

KW - primers

KW - recombinant DNA

KW - ribosome binding

KW - ribozyme

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Antisense RNA: its functions and applications in gene regulation - a review

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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