TY - JOUR
T1 - Apoer2
T2 - A Reelin receptor to remember
AU - D'Arcangelo, Gabriella
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2005/8/18
Y1 - 2005/8/18
N2 - The extracellular protein Reelin is crucial for neuronal positioning during brain development, but its expression persists long after cell migration is completed. In this issue of Neuron, Beffert et al. demonstrate that Reelin exerts an additional function in the mature brain, to modulate synaptic plasticity and to favor memory formation. This activity is carried out exquisitely by the Apoer2 receptor and critically requires the presence of an alternatively spliced exon. This exon encodes an intracellular domain that interacts with postsynaptic proteins and promotes binding and phosphorylation of NMDA receptors.
AB - The extracellular protein Reelin is crucial for neuronal positioning during brain development, but its expression persists long after cell migration is completed. In this issue of Neuron, Beffert et al. demonstrate that Reelin exerts an additional function in the mature brain, to modulate synaptic plasticity and to favor memory formation. This activity is carried out exquisitely by the Apoer2 receptor and critically requires the presence of an alternatively spliced exon. This exon encodes an intracellular domain that interacts with postsynaptic proteins and promotes binding and phosphorylation of NMDA receptors.
UR - http://www.scopus.com/inward/record.url?scp=23744451542&partnerID=8YFLogxK
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U2 - 10.1016/j.neuron.2005.08.001
DO - 10.1016/j.neuron.2005.08.001
M3 - Short survey
C2 - 16102527
AN - SCOPUS:23744451542
VL - 47
SP - 471
EP - 473
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 4
ER -