Apoptosis, blood-brain barrier, and subarachnoid hemorrhage

J. H. Zhang, I. Gules, M. Satoh, A. Nanda

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

This study was undertaken to investigate the role of apoptosis in the integrity of blood-brain barrier (BBB) in subarachnoid hemorrhage (SAH). BBB permeability changes were examined and found increased on day 7 in a double hemorrhage rat model using Evans blue dye. The BBB permeability increase is coincidental to brain microvascular endothelial cell apoptosis (expression of caspase-8 and -9) occurring on Day 7. However, caspase-8 and caspase-9 inhibitors failed to protect the BBB. Considering that treatment did not completely inhibit apoptosis in brain microvascular endothelial cells, higher doses, earlier and/or multiple applications, and, possibly, more potent caspase inhibitors may be needed.

Original languageEnglish (US)
Pages (from-to)483-487
Number of pages5
JournalActa Neurochirurgica, Supplementum
Issue number86
DOIs
StatePublished - 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Keywords

  • Apoptosis
  • Blood-brain barrier
  • Caspase
  • Rat
  • Subarachnoid hemorrhage

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