The purpose of the present study was to investigate the application of anti-CD3-treated lymphocytes as stimulator cells in human one-way autologous mixed lymphocyte cultures (MLC) for the generation of suppressor cells. MLC-activated CD4-CD8+ CD16- T cells were non-cytotoxic, while they down-regulated the proliferation of autologous (but not allogeneic) responder lymphocytes in allogeneic test MLC.
All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Anti-CD3-induced T cell activation
- Autologous mixed lymphocyte culture
- Suppressor T cell