Application of anti-CD3-treated lymphocytes as stimulator cells in human autologous mixed lymphocyte cultures for generation of autorestricted CD8+ suppressor T cells

K. E. Balashov, B. D. Brondz

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of the present study was to investigate the application of anti-CD3-treated lymphocytes as stimulator cells in human one-way autologous mixed lymphocyte cultures (MLC) for the generation of suppressor cells. MLC-activated CD4-CD8+ CD16- T cells were non-cytotoxic, while they down-regulated the proliferation of autologous (but not allogeneic) responder lymphocytes in allogeneic test MLC.

Original languageEnglish (US)
Pages (from-to)233-236
Number of pages4
JournalImmunology Letters
Volume31
Issue number3
DOIs
StatePublished - Feb 15 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Keywords

  • Anti-CD3-induced T cell activation
  • Autologous mixed lymphocyte culture
  • Suppressor T cell

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