Application of Toxicogenomics in Predicting Hepatotoxicity - Potentials and Challenges

Wen Lin, Guoxiang Shen, Tin Oo Khor, Ah Ng Tony Kong

Research output: Chapter in Book/Report/Conference proceedingChapter

Original languageEnglish (US)
Title of host publicationHepatotoxicity
Subtitle of host publicationFrom Genomics to in vitro and in vivo Models
PublisherJohn Wiley & Sons, Ltd
Pages447-463
Number of pages17
ISBN (Print)9780470057162
DOIs
StatePublished - Feb 27 2008

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Keywords

  • Acute and chronic liver diseases
  • Drug withdrawal post-marketing
  • Drug-induced hepatotoxicity
  • Drug-induced idiosyncratic hepatotoxicity
  • Gene expression profiles
  • Genome-scale DNA sequences
  • Microarray-based toxicogenomics
  • Potential liver toxicity
  • Primary upstream events
  • Serum toxicity biomarkers level

Cite this

Lin, W., Shen, G., Khor, T. O., & Tony Kong, A. N. (2008). Application of Toxicogenomics in Predicting Hepatotoxicity - Potentials and Challenges. In Hepatotoxicity: From Genomics to in vitro and in vivo Models (pp. 447-463). John Wiley & Sons, Ltd. https://doi.org/10.1002/9780470516751.ch17