TY - JOUR
T1 - Applications and delivery mechanisms of hyaluronic acid used for topical/transdermal delivery – A review
AU - Zhu, Jieyu
AU - Tang, Xudong
AU - Jia, Yan
AU - Ho, Chi Tang
AU - Huang, Qingrong
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/3/30
Y1 - 2020/3/30
N2 - The purpose of this review is to introduce the functionalities of hyaluronic acid (HA) and its potential application as an effective carrier for topical/transdermal delivery. Specifically, several delivery mechanisms of HA were summarized here in order to explain its potential permeation-enhancing roles for the skin, which includes receptor-based delivery pathway, skin hydration, hydrophobic interaction with stratum corneum, bioadhesive properties, and viscoelastic properties. To achieve the optimum delivery efficacy for bioactive compounds at different target layers of the skin, HA with various molecular weights and chemical modifications were applied to design different delivery systems, including hydrogel, nanoemulsion, microemulsion, prodrug, microneedle, liposome/hyalurosome. Delivery efficacy has been evaluated using in vitro Franz Cell Diffusion method and/or in vivo animal models. Throughout this review, it was confirmed that HA could be an effective carrier for both topical and transdermal deliveries due to its unique viscoelasticity, biocompatibility, biodegradability, non-immunogenicity, and biomedical benefits for the skin.
AB - The purpose of this review is to introduce the functionalities of hyaluronic acid (HA) and its potential application as an effective carrier for topical/transdermal delivery. Specifically, several delivery mechanisms of HA were summarized here in order to explain its potential permeation-enhancing roles for the skin, which includes receptor-based delivery pathway, skin hydration, hydrophobic interaction with stratum corneum, bioadhesive properties, and viscoelastic properties. To achieve the optimum delivery efficacy for bioactive compounds at different target layers of the skin, HA with various molecular weights and chemical modifications were applied to design different delivery systems, including hydrogel, nanoemulsion, microemulsion, prodrug, microneedle, liposome/hyalurosome. Delivery efficacy has been evaluated using in vitro Franz Cell Diffusion method and/or in vivo animal models. Throughout this review, it was confirmed that HA could be an effective carrier for both topical and transdermal deliveries due to its unique viscoelasticity, biocompatibility, biodegradability, non-immunogenicity, and biomedical benefits for the skin.
KW - Hyaluronic acid
KW - Hydrogel
KW - Liposome/hyalurosome
KW - Microneedle
KW - Nano/micro-emulsion
KW - Prodrug
KW - Skin permeation
KW - Topical/transdermal delivery
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U2 - 10.1016/j.ijpharm.2020.119127
DO - 10.1016/j.ijpharm.2020.119127
M3 - Review article
C2 - 32036009
AN - SCOPUS:85079245970
SN - 0378-5173
VL - 578
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
M1 - 119127
ER -