Aptamer-conjugated nanomaterials and their applications

Liu Yang; Xiaobing Zhang; Mao Ye; Jianhui Jiang; Ronghua Yang; Ting Fu; Yan Chen; Kemin Wang; Chen Liu; Weihong Tan

doi:10.1016/j.addr.2011.10.002

Aptamer-conjugated nanomaterials and their applications

Liu Yang, Xiaobing Zhang, Mao Ye, Jianhui Jiang, Ronghua Yang, Ting Fu, Yan Chen, Kemin Wang, Chen Liu, Weihong Tan

Research output: Contribution to journal › Review article › peer-review

184 Scopus citations

Abstract

The combination of aptamers with novel nanomaterials, including nanomaterial-based aptamer bioconjugates has attracted considerable interest and has led to a wide variety of applications. In this review, we discuss how a variety of nanomaterials, including gold, silica and magnetic nanoparticles, as well as carbon nanotubes, hydrogels, liposomes and micelles, have been used to functionalize aptamers for a variety of applications. These aptamer functionalized materials have led to advances in amplified biosensing, cancer cell-specific recognition, high-efficiency separation, and targeted drug delivery.

Original language	English (US)
Pages (from-to)	1361-1370
Number of pages	10
Journal	Advanced Drug Delivery Reviews
Volume	63
Issue number	14-15
DOIs	https://doi.org/10.1016/j.addr.2011.10.002
State	Published - Nov 2011
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmaceutical Science

Keywords

Aptamers
Biosensors
Drug delivery
Nanomaterials

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10.1016/j.addr.2011.10.002

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title = "Aptamer-conjugated nanomaterials and their applications",

abstract = "The combination of aptamers with novel nanomaterials, including nanomaterial-based aptamer bioconjugates has attracted considerable interest and has led to a wide variety of applications. In this review, we discuss how a variety of nanomaterials, including gold, silica and magnetic nanoparticles, as well as carbon nanotubes, hydrogels, liposomes and micelles, have been used to functionalize aptamers for a variety of applications. These aptamer functionalized materials have led to advances in amplified biosensing, cancer cell-specific recognition, high-efficiency separation, and targeted drug delivery.",

keywords = "Aptamers, Biosensors, Drug delivery, Nanomaterials",

author = "Liu Yang and Xiaobing Zhang and Mao Ye and Jianhui Jiang and Ronghua Yang and Ting Fu and Yan Chen and Kemin Wang and Chen Liu and Weihong Tan",

note = "Funding Information: This work was supported by the National Natural Science Foundation of China (20975034) and the National Key Scientific Program of China (2011CB911001, 2011CB911003) . This work is also supported by grants awarded by the National Institutes of Health (GM066137, GM079359 and CA133086) . We also acknowledge the Interdisciplinary Center for Biotechnology Research (ICBR) at the University of Florida. ",

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month = nov,

doi = "10.1016/j.addr.2011.10.002",

language = "English (US)",

volume = "63",

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journal = "Advanced Drug Delivery Reviews",

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AU - Yang, Liu

AU - Zhang, Xiaobing

AU - Ye, Mao

AU - Jiang, Jianhui

AU - Yang, Ronghua

AU - Fu, Ting

AU - Chen, Yan

AU - Wang, Kemin

AU - Liu, Chen

AU - Tan, Weihong

N1 - Funding Information: This work was supported by the National Natural Science Foundation of China (20975034) and the National Key Scientific Program of China (2011CB911001, 2011CB911003) . This work is also supported by grants awarded by the National Institutes of Health (GM066137, GM079359 and CA133086) . We also acknowledge the Interdisciplinary Center for Biotechnology Research (ICBR) at the University of Florida.

PY - 2011/11

Y1 - 2011/11

N2 - The combination of aptamers with novel nanomaterials, including nanomaterial-based aptamer bioconjugates has attracted considerable interest and has led to a wide variety of applications. In this review, we discuss how a variety of nanomaterials, including gold, silica and magnetic nanoparticles, as well as carbon nanotubes, hydrogels, liposomes and micelles, have been used to functionalize aptamers for a variety of applications. These aptamer functionalized materials have led to advances in amplified biosensing, cancer cell-specific recognition, high-efficiency separation, and targeted drug delivery.

AB - The combination of aptamers with novel nanomaterials, including nanomaterial-based aptamer bioconjugates has attracted considerable interest and has led to a wide variety of applications. In this review, we discuss how a variety of nanomaterials, including gold, silica and magnetic nanoparticles, as well as carbon nanotubes, hydrogels, liposomes and micelles, have been used to functionalize aptamers for a variety of applications. These aptamer functionalized materials have led to advances in amplified biosensing, cancer cell-specific recognition, high-efficiency separation, and targeted drug delivery.

KW - Aptamers

KW - Biosensors

KW - Drug delivery

KW - Nanomaterials

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ER -

Aptamer-conjugated nanomaterials and their applications

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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