Aptamer-conjugated nanomaterials and their applications

Liu Yang, Xiaobing Zhang, Mao Ye, Jianhui Jiang, Ronghua Yang, Ting Fu, Yan Chen, Kemin Wang, Chen Liu, Weihong Tan

Research output: Contribution to journalReview articlepeer-review

147 Scopus citations

Abstract

The combination of aptamers with novel nanomaterials, including nanomaterial-based aptamer bioconjugates has attracted considerable interest and has led to a wide variety of applications. In this review, we discuss how a variety of nanomaterials, including gold, silica and magnetic nanoparticles, as well as carbon nanotubes, hydrogels, liposomes and micelles, have been used to functionalize aptamers for a variety of applications. These aptamer functionalized materials have led to advances in amplified biosensing, cancer cell-specific recognition, high-efficiency separation, and targeted drug delivery.

Original languageEnglish (US)
Pages (from-to)1361-1370
Number of pages10
JournalAdvanced Drug Delivery Reviews
Volume63
Issue number14-15
DOIs
StatePublished - Nov 2011

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Keywords

  • Aptamers
  • Biosensors
  • Drug delivery
  • Nanomaterials

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