Aptamers generated by Cell SELEX for biomarker discovery

Youngmi Kim, Chen Liu, Weihong Tan

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations

Abstract

Biomarker discovery is essential to the advancement of our knowledge about diseases and to the development of new strategies for treatment and therapy. Among the newest technologies in this rapidly growing field is a process termed Cell SELEX by which a panel of aptamers can be generated to specifically target disease cells. Thus, Cell SELEX, together with the in vitro selection of aptamers, brings a promising approach to accelerate the progress of biomarker discovery. In this review, the Cell SELEX method and potential uses of selected aptamers are discussed. In addition, identification of potential biomarkers by using cell-binding aptamers is addressed. We believe that using the Cell SELEX strategy represents a significant improvement over current approaches to biomarker identification by the simplicity, efficiency and specificity of its application.

Original languageEnglish (US)
Pages (from-to)193-202
Number of pages10
JournalBiomarkers in Medicine
Volume3
Issue number2
DOIs
StatePublished - 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Clinical Biochemistry
  • Biochemistry, medical

Keywords

  • Aptamers
  • Biomarker discovery
  • Cancer
  • Cell SELEX

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