Aptatag-based multiplexed assay for protein detection by surface-enhanced Raman spectroscopy

Laura Fabris, Martin Schierhorn, Martin Moskovits, Guillermo C. Bazan

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Silver-nanoparticle dimers held together by a Raman reporter, capped with DNA aptamers and stabilized by polyethylene glycol chains, can be used to develop a multiplexed heterogeneous bioassay for protein detection with high sensitivity and selectivity.

Original languageEnglish (US)
Pages (from-to)1550-1557
Number of pages8
JournalSmall
Volume6
Issue number14
DOIs
StatePublished - Jul 19 2010

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Engineering (miscellaneous)
  • Biotechnology
  • General Materials Science
  • Biomaterials

Keywords

  • Aptamers
  • Bioassays
  • Nanoparticles
  • Proteins
  • Raman spectroscopy

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