Aromatic hydrogen bond in sequence-specific protein DNA recognition

G. Parkinson; A. Gunasekera; J. Vojtechovsky; X. Zhang; T. A. Kunkel; H. Berman; R. H. Ebright

doi:10.1038/nsb1096-837

Aromatic hydrogen bond in sequence-specific protein DNA recognition

G. Parkinson, A. Gunasekera, J. Vojtechovsky, X. Zhang, T. A. Kunkel, H. Berman, R. H. Ebright

Research output: Contribution to journal › Article › peer-review

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Abstract

An aromatic hydrogen bond-an interaction between the π-electron cloud of an aromatic ring and a hydrogen-bond donor-can substitute for a conventional hydrogen bond in sequence-specific protein-DNA interactions and can contribute 0.5-1 kcal mol^-1 to binding and 1-2 kcal mol^-1 to specificity.

Original language	English (US)
Pages (from-to)	837-841
Number of pages	5
Journal	Nature Structural Biology
Volume	3
Issue number	10
DOIs	https://doi.org/10.1038/nsb1096-837
State	Published - 1996

All Science Journal Classification (ASJC) codes

Structural Biology
Biochemistry
Genetics

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abstract = "An aromatic hydrogen bond-an interaction between the π-electron cloud of an aromatic ring and a hydrogen-bond donor-can substitute for a conventional hydrogen bond in sequence-specific protein-DNA interactions and can contribute 0.5-1 kcal mol-1 to binding and 1-2 kcal mol-1 to specificity.",

author = "G. Parkinson and A. Gunasekera and J. Vojtechovsky and X. Zhang and Kunkel, {T. A.} and H. Berman and Ebright, {R. H.}",

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AU - Zhang, X.

AU - Kunkel, T. A.

AU - Berman, H.

AU - Ebright, R. H.

PY - 1996

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AB - An aromatic hydrogen bond-an interaction between the π-electron cloud of an aromatic ring and a hydrogen-bond donor-can substitute for a conventional hydrogen bond in sequence-specific protein-DNA interactions and can contribute 0.5-1 kcal mol-1 to binding and 1-2 kcal mol-1 to specificity.

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Aromatic hydrogen bond in sequence-specific protein DNA recognition

Abstract

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