Aromatic-Turmerone Attenuates LPS-Induced Neuroinflammation and Consequent Memory Impairment by Targeting TLR4-Dependent Signaling Pathway

Min Chen, Yuan Yuan Chang, Shun Huang, Li Hang Xiao, Wei Zhou, Lan Yue Zhang, Chun Li, Ren Ping Zhou, Jian Tang, Li Lin, Zhi Yun Du, Kun Zhang

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Scope: Curcuma longa (turmeric) is a folk medicine in South and Southeast Asia, which has been widely used to alleviate chronic inflammation. Aromatic-turmerone is one of the main components abundant in turmeric essential oil. However, little information is available from controlled studies regarding its biological activities and underlying molecular mechanisms against chronic inflammation in the brain. In the current study, we employed a classical LPS model to study the effect and mechanism of aromatic-turmerone on neuroinflammation. Methods and results: The effects of aromatic-turmerone were studied in LPS-treated mice and BV2 cells. The cognitive function assays, protein analyses, and histological examination were performed. Oral administration of aromatic-turmerone could reverse LPS-induced memory disturbance and normalize glucose intake and metabolism in the brains of mice. Moreover, aromatic-turmerone significantly limited brain damage, through inhibiting the activation of microglia and generation of inflammatory cytokines. Further study in vitro revealed that aromatic-turmerone targeted Toll-like receptor 4 mediated downstream signaling, and lowered the release of inflammatory mediators. Conclusion: These observations indicate that aromatic-turmerone is effective in preventing brain damage caused by neuroinflammation and may be useful in the treatment of neuronal inflammatory diseases.

Original languageEnglish (US)
Article number1700281
JournalMolecular Nutrition and Food Research
Volume62
Issue number2
DOIs
StatePublished - Jan 2018

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science

Keywords

  • Aromatic-turmerone
  • LPS
  • Memory impairments
  • Neuroinflammation
  • Toll-like receptor

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