Arthritis and diagnostics in lyme disease

Javier A. Quintero, Raluchukwu Attah, Reena Khianey, Eugenio Capitle, Steven E. Schutzer

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The diagnosis of Lyme disease, caused by Borrelia burgdorferi, is clinical but frequently supported by laboratory tests. Lyme arthritis is now less frequently seen than at the time of its discovery. However, it still occurs, and it is important to recognize this, the differential diagnoses, and how laboratory tests can be useful and their limitations. The most frequently used diagnostic tests are antibody based. However, antibody testing still suffers from many drawbacks and is only an indirect measure of exposure. In contrast, evolving direct diagnostic methods can indicate active infection.

Original languageEnglish (US)
Article number18
JournalTropical Medicine and Infectious Disease
Issue number1
StatePublished - 2021

All Science Journal Classification (ASJC) codes

  • General Immunology and Microbiology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


  • Antibiotic refractory arthritis
  • Antibodies
  • Borrelia burgdorferi
  • Direct testing
  • Disease modifying antirheumatic drugs
  • Indirect testing
  • Inflammatory arthritis
  • Lyme arthritis
  • Lyme disease
  • Tumor necrosis factor inhibitors


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