Aspergillus flavus genomics as a tool for studying the mechanism of aflatoxin formation

Jiujiang Yu, Gary A. Payne, William C. Nierman, Masayuki Machida, Joan W. Bennett, Bruce C. Campbell, Jane F. Robens, Deepak Bhatnagar, Ralph A. Dean, Thomas E. Cleveland

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Aspergillus flavus is a weak pathogen that infects plants, animals and humans. When it infects agricultural crops, however, it produces one of the most potent carcinogens known (aflatoxins). To devise strategies to control aflatoxin contamination of pre-harvest agricultural crops and post-harvest grains during storage, we launched the A. flavus genomics program. The major objective of this program is the identification of genes involved in aflatoxin biosynthesis and regulation, as well as in pathogenicity, to gain a better understanding of the mechanism of aflatoxin formation. The sequencing of A. flavus whole genome has been completed. Initial annotation of the sequence revealed that there are about 13,071 genes in the A. flavus genome. Genes which potentially encode for enzymes involved in secondary metabolite production in the A. flavus genome have been identified. Preliminary comparative genome analysis of A. flavus with A. oryzae is summarized here.

Original languageEnglish (US)
Pages (from-to)1152-1157
Number of pages6
JournalFood Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment
Volume25
Issue number9
DOIs
StatePublished - Sep 1 2008

All Science Journal Classification (ASJC) codes

  • Food Science
  • Chemistry(all)
  • Toxicology
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Keywords

  • Aflatoxins
  • Aspergillus
  • Expressed Sequence tags
  • Gene profiling
  • Genomics
  • Microarrays
  • Mycotoxins
  • Toxigenic fungi

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