Aspergillus flavus genomics: Gateway to human and animal health, food safety, and crop resistance to diseases

Jiujiang Yu, Thomas E. Cleveland, William C. Nierman, Joan W. Bennett

Research output: Contribution to journalReview articlepeer-review

124 Scopus citations


Aspergillus flavus is an imperfect filamentous fungus that is an opportunitic pathogen causing invasive and non-invasive aspergillosis in humans, animals, and insects. It also causes allergic reactions in humans. A. flavus infects agricultural crops and stored grains and produces the most toxic and potent carcinogic metabolites such as aflatoxins and other mycotoxins. Breakthroughs in A. flavus genomics may lead to improvement in human health, food safety, and agricultural economy. The availability of A. flavus genomic data marks a new era in research for fungal biology, medical mycology, agricultural ecology, pathogenicity, mycotoxin biosynthesis, and evolution. The availability of whole genome microarrays has equipped scientists with a new powerful tool for studying gene expression under specific conditions. They can be used to identify genes responsible for mycotoxin biosynthesis and for fungal infection in humans, animals and plants. A. flavus genomics is expected to advance the development of therapeutic drugs and to provide information for devising strategies in controlling diseases of humans and other animals. Further, it will provide vital clues for engineering commercial crops resistant to fungal infection by incorporating antifungal genes that may prevent aflatoxin contamination of agricultural harvest.

Original languageEnglish (US)
Pages (from-to)194-202
Number of pages9
JournalRevista Iberoamericana de Micologia
Issue number4
StatePublished - Dec 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Infectious Diseases


  • Aflatoxicosis
  • Aflatoxins
  • Aspergillosis
  • Crop resistance
  • Food Safety
  • Mycotoxins


Dive into the research topics of 'Aspergillus flavus genomics: Gateway to human and animal health, food safety, and crop resistance to diseases'. Together they form a unique fingerprint.

Cite this