Assembly of highly aligned DNA strands onto Si chips

Jianming Zhang, Yufeng Ma, Sylwia Stachura, Huixin He

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


This paper reports a robust and efficient approach to assemble highly aligned DNA strands onto Si chips. The method combines advantages from molecular combing and microcontact printing to realize controlling both the density and direction of DNA strands on the Si chip. In addition, it also can be utilized to prepare stretched DNA structures on solid surfaces. Compared to approaches that use molecular combing directly on silanated surfaces, the stretched single-chain DNA structures are straighter. Furthermore, by exploiting the hydrophobia property of the intrinsic poly(dimethylsiloxane) stamp, this study also describes a simple way to produce straight bundled DNA arrays on Si and other substrates.

Original languageEnglish (US)
Pages (from-to)4180-4184
Number of pages5
Issue number9
StatePublished - Apr 26 2005

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry


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