Assignment of a gene for adenosine deaminase to human chromosome 20

J. A. Tischfield, R. P. Creagan, E. A. Nichols, F. H. Ruddle

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Evidence, based on five series of mouse-human somatic cell hybrid clones, is presented for assignment of a human gene for adenosine deaminase (ADA: EC 3.5.4.4) to chromosome 20. The human form of adenosine deaminase expressed by the hybrid cells apearcd to be identical to the isozyme found in erythrocytes, judging from its electro-phoretic mobility and reactions with p-chloromercuribenzoic acid (PCMB). Absence of ADA activity has been associated with a combined immunodeficiency syndrome. The relationship of our data to hypotheses concerning this association is discussed.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalHuman Heredity
Volume24
Issue number1
DOIs
StatePublished - Jan 1 1974
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Keywords

  • ADA
  • Gene assignment
  • Human Chromosome 20
  • Somatic cell hybridization

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