Evidence, based on five series of mouse-human somatic cell hybrid clones, is presented for assignment of a human gene for adenosine deaminase (ADA: EC 22.214.171.124) to chromosome 20. The human form of adenosine deaminase expressed by the hybrid cells apearcd to be identical to the isozyme found in erythrocytes, judging from its electro-phoretic mobility and reactions with p-chloromercuribenzoic acid (PCMB). Absence of ADA activity has been associated with a combined immunodeficiency syndrome. The relationship of our data to hypotheses concerning this association is discussed.
All Science Journal Classification (ASJC) codes
- Gene assignment
- Human Chromosome 20
- Somatic cell hybridization