Association between personality traits and the dopamine receptor (D4DR) exon III polymorphism

R. Corsico, P. Manowitz, M. Ricketts, R. Hammer, A. Corsico, O. Pessino, M. S. Guerrero

Research output: Contribution to journalArticlepeer-review


The purpose of this study was to investigate a previously reported relationship between the Dopamine D4 receptor gene (D4DR) polymorphism and Novelty Seeking (Ebstein RP, Novick O, et al., 1996; Benjamin J, Li L, 1996; Ronai Z, Szekely A, 2001). This study comprised 206 subjects (98 Male and 108 Female), who were Argentinean University students, mean age 23 of both sexes. Two different personality inventories were used; one was the Eysenck Personality Questionnaire and the other, Cloningeŕs Temperament and Character Inventory. Novelty Seeking was chosen as phenotypic marker and Personality trait variability was matched to the polymorphisms of the D4DR. Mean scores for Female were: 19.69 for the short form and 19.39 for the long form whereas mean scores for Men were 19.05 for the short form and 21.83 for the long form. Conclusion: Genotype effect was found for males but not for females. Mean for males with the long genotype was approximately 3 points higher than the mean for the males with the short genotype for Novelty Seeking.

Original languageEnglish (US)
Pages (from-to)618
Number of pages1
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Issue number7
StatePublished - Oct 8 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience


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